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Even moderate alcohol drinking raises hyperuricemia risk in men, study claims

China: A large cross-sectional study in Chongqing, China, has shed light on the association between alcohol consumption and the risk of hyperuricaemia among adults.

The study findings published in BMJ Open have demonstrated the frequency and degree of alcohol consumption to be the risk factors for hyperuricemia (HUA), especially in males. Moderate drinking was also observed to be a risk factor for HUA among men in the study.

"Different from the benefits of moderate drinking found in other research, HUA risk among moderate drinkers is 1.23 times than that of never drinkers among those in males," the researchers reported. "HUA risk is higher for those who usually drink alcohol l than for those who never drink alcohol among the total population."

"The risk of HUA caused by harmful drinking is the highest, which is 1.81 times that of never-drinkers among the total population and 2.13 times than that of never-drinkers among males," they added, "However, among females, HUA risk was not found to change with drinking."

Hyperuricaemia is becoming a common chronic disease with a worldwide economic and health burden. Considering the widespread consumption of alcohol in the world, some clinicians' review of dietary advice for HUA and gout patients shows that the most general advice is complete avoidance or restriction of alcohol intake, in which this suggested frequency is usually beyond weight loss.

The influence of drinking frequency and degree on hyperuricaemia needs further exploration. Therefore, Siyu Chen, School of Public Health, Chongqing Medical University, Chongqing, China, and colleagues aimed to investigate the relationship between alcohol consumption and hyperuricaemia based on a large population.

The researchers enrolled 20,833 participants aged 30–79 years in the China Multi-Ethnic Cohort, Chongqing region. The serum levels of fasting blood glucose, uric acid, and blood lipids were tested. A standardised questionnaire was used to collect basic demographic statistics such as gender, age, education level, marital status, detailed information on alcohol consumption, and family annual income.

The study led to the following findings:

  • After controlling for potential confounders, compared with participants who never consumed alcohol, participants who drank 3–5 days per week had the highest HUA risk (OR: 1.51) and those who drank alcohol harmfully had the highest risk of HUA (OR: 1.81).
  • Those who drank moderately had no significant association with the risk of HUA. However, among men, compared with participants who never consumed alcohol, those who drank moderately were also a risk factor for HUA (OR: 1.23) and those who drank alcohol harmfully had the highest risk of HUA (OR: 2.13).
  • Compared with participants who drank alcohol moderately, the OR for those who drank alcohol harmfully had the highest risk of HUA was 1.88, and the corresponding OR for each level increment in the degree of alcohol consumption was 1.22.
  • Among men, compared with participants who drank alcohol moderately, those who drank alcohol harmfully had the highest risk of HUA (OR: 1.93), and the corresponding OR for each level increment in the degree of alcohol consumption was 1.24.

The study demonstrated a positive relation between the frequency and degree of alcohol consumption and the risk of hyperuricemia. This positive connection was obvious among men, but weak among women. Moderate drinking was also revealed to be a risk factor for HUA among men in the study.

"There is a need for further interventional and prospective research to verify the causal relationship and clarify the specific mechanism," they concluded.

Reference:

Chen S, Ding R, Tang X, et alAssociation between alcohol consumption and risk of hyperuricaemia among adults: a large cross-sectional study in Chongqing, ChinaBMJ Open 2023;13:e074697. doi: 10.1136/bmjopen-2023-074697

1 year 7 months ago

Medicine,Nephrology,Orthopaedics,Diet and Nutrition,Diet and Nutrition News,Medicine News,Nephrology News,Orthopaedics News,Top Medical News,Latest Medical News

Jamaica Observer

Problems with dental implants

DENTAL implants are a groundbreaking modern solution to a tooth loss problem.

What problems are common with dental implants? What can I do about them myself, and what requires a professional?

We're here to address your most pressing questions and concerns around problems with dental implants.

DENTAL implants are a groundbreaking modern solution to a tooth loss problem.

What problems are common with dental implants? What can I do about them myself, and what requires a professional?

We're here to address your most pressing questions and concerns around problems with dental implants.

Dental implant overview

Dental implants are a high-tech solution used to replace your missing teeth; your natural tooth root is replaced with a titanium screw that fuses to your jawbone during the implant process. This titanium root acts as an anchor for a dental restoration, typically either a crown, bridge, or dentures.

These permanent solutions can improve your chewing and speaking ability, along with your look. Even better, they don't get cavities but still require proper care to avoid other problems.

Reasons your dental professional may recommend dental implants include:

• Cavities

• Fractured or broken teeth

• Excessive tooth wear from grinding your teeth (also known as bruxism)

• Injury

If you're considering implants it's a great idea to consult with your dental professional regarding your risk factors that impact your chance of complications.

Problems with implants

According to research, implants are considered safe and there's only a five per cent chance that you will reject your implant. Although these risks are usually slight and can be treated by your dental professional, various complications can arise.

Complications of dental implants can include:

• Infection around the implant

• Damage to blood vessels, teeth, or other tissue

• Nerve damage leading to pain, numbness, or a tingling sensation

• Issues with your sinuses (in cases where the implant is placed in the upper jaw).

The full process of getting dental implants can take several months as it can include tooth extraction, preparation, implantation, healing, and placement of the restoration. For this reason it's vital to give yourself the best chance of successful healing and integration of the implant with your natural bone.

Your risk for complications may be increased if you:

• Are in poor health, regardless of age

• Smoke or use tobacco products

• Have diabetes, leukaemia, or other chronic illness

•Received radiation therapy in the past

• Do not follow the aftercare instructions by your dental professional carefully

• Do not take medications as prescribed.

We recommend contacting your dental professional if you experience signs of infection, unusual swelling, pain, or have a difficult time chewing or speaking after your implant procedure.

Treatment and prevention

Implants can provide a solution for the remainder of life for some people while others experience complications or require additional treatment. Even though the implants and restoration are not natural teeth, your diet and oral care routine are still essential in maintaining their long-term success and your health.

Treatment for complications like loosening or infection typically includes removal and re-implantation by your dental professional. It may reassure you to know that even if your implant fails, re-implantation is successful about 90 per cenyt of the time.

You can reduce your chance of complications with dental implants by:

• Avoiding smoking and tobacco products

• Preventing gum disease through proper diet and oral care

• Brushing for two minutes twice daily

• Cleaning between your teeth using a flossing device once daily

• Scheduling regular visits with your dental professional

• Properly caring for your dental restorations

• Not grinding your teeth (consider a mouthguard at night to help reduce the damage).

Here are some steps to reduce discomfort following dental implantation:

• Rinse with a mix of three per cent hydrogen peroxide and equal parts water, or antibacterial mouth rinse

• Avoid hard, sticky, or chewy foods that could irritate your sensitive mouth.

• Take over-the-counter medications as instructed on the packaging.

• Use a cold compress or ice pack by applying it to the affected area outside your cheek for 20 minutes, three times a day.

Dental implants have positively affected the lives of many, thanks to the ability of titanium to integrate into your bone. Even though your restorations can't get cavities it's vital to maintain a proper diet and dental routine to avoid complications.

Dr Sharon Robinson, DDS, has offices at Dental Place Cosmetix Spa, located at shop #5, Winchester Business Centre, 15 Hope Road, Kingston 10. Dr Robinson is an adjunct lecturer at the University of Technology, Jamaica, School of Oral Health Sciences. She may be contacted at 876-630-4710 and 876-441-4872 (
WhatsApp
). Like their
Facebook
and
Instagram
pages, Dental Place Cosmetix Spa.

1 year 7 months ago

Jamaica Observer

Environmental data — a primary tool for reducing mosquito-borne diseases

EARLY theories of health and medicine have posited mysterious origins for numerous diseases as scientists have tried various experiments and theories in order to curtail the spread of infectious illnesses.

In the 18th century mosquito-borne diseases such as malaria were thought to be caused by bad air ("mala aria") from marshlands, however in later years other scientists made new discoveries and realised that infectious illnesses were caused by a germ, giving rise to the germ theory. This theory of an infectious disease being caused by a germ was the construct for a new approach to managing infectious diseases globally. However, as time evolves, more empirical evidence has been found and used in various fields of medicine to reduce the public health burden through the implementation of evidence-based interventions and strategies.

Mosquito-borne diseases have continued to be a grave global public health issue, contributing to considerable economic cost in many countries. Diseases such as malaria, yellow fever and dengue are endemic in most of the tropical and subtropical parts of the world, and since January 2023 there have been more than 1,000 confirmed cases of dengue in Jamaica. Many Caribbean states have also experienced increased numbers of mosquito-borne diseases since the beginning of the year, despite the implementation of numerous mosquito-control strategies.

Strengthen entomological capacities through better use of environmental data

Many factors such as climate change, unplanned urbanisation, human behaviour, and globalisation are contributing to the emergence and re-emergence of mosquito-borne diseases in recent years. Using data captured from environmental surveillance is therefore necessary to combat these challenges and ensure the effective implementation of mosquito-control programmes. Mosquito-control programmes devoid of scientifically gathered data are often plagued with repeated problems and ineffective use of resources. Constant gathering and use of data, such as the mosquito index — in particular breteau and container indices), identification of potential and common sites for mosquito breeding, distribution of wetlands, levels of precipitation, atmospheric temperatures and wind speed — allow for implementation of effective strategies necessary to curtail incidents of mosquito-borne diseases. Dengue fever is a major public health problem throughout most tropical and some subtropical regions worldwide, and so is Zika fever and other arboviral infections such as chikungunya. Malaria is endemic to many Caribbean countries and remains a major killer of children, particularly in sub-Saharan Africa where it results in the death of a child every two minutes. Environmental data, if captured and used properly, can strengthen entomological capacities as the information provides an understanding of patterns, causes and effects of mosquito-borne diseases, as well as areas that require priority attention to avert possible outbreaks of mosquito-borne diseases.

Common failings of mosquito-control programmes:

1. Failure to capture and incorporate environmental data such as atmospheric temperatures, levels of precipitation, wind speed and land cover conditions when planning and implementing mosquito-control strategies.

The atmospheric temperature of an area and land cover conditions are useful pieces of information that can be used to predict the likelihood of mosquito proliferation atmospheric temperatures within particular ranges that encourage the reproduction of mosquitoes. Female mosquitoes cannot develop eggs at temperatures below 50°F (10°C). Atmospheric temperatures of 27-32 °C are favourable for the rapid completion of the mosquito life cycle. The condition of land cover also has a direct bearing on the effectiveness of mosquito-control strategies. In urban areas of Brazil, environmental surveillance data shows a positive relationship between environmental temperatures, land cover, and Aedes agypti mosquito breeding. In Brazil, roofs made of asbestos and concrete have also been proven to provide favourable sites for Aedes aeygptyi breeding. Mosquitoes are biting nuisances, resulting in cases of urticarial rashes and other dermatological infections. Effective programmes are therefore necessary for a multiplicity of reasons.

2. Failure to adequately incorporate and use technology when implementing mosquito-control strategies.

It is a proven fact that GIS (geographic information systems) technology has significantly transformed mosquito-control strategies in many countries worldwide. GIS enables the visualisation and analysis of geographical data, thereby providing valuable insights into mosquito population dynamics. GIS can be used to map mosquito larvae and adult habitats as well as human populations which are at a greater risk for mosquito exposure and mosquito-borne infections. Through GIS mapping, areas of priority that require ongoing entomological management can be easily identified. Using GIS technology permits the development and use of mosquito-control treatment area maps and leads to better schedules for mosquito-control activities — all of which are necessary to ensure proper management and use of programme resources.

3. Relaxing mosquito-control activities in dry months.

At no time should mosquito-control activities be relaxed. While it is a known fact that some species of female mosquitoes lay their eggs above the waterline in water-holding containers it is also proven scientifically that other species will lay their eggs on damp soil — even when there is no flooding. Water levels on land of 12.7 mm (1/2 inch) or above can cause mosquito eggs to hatch. GIS technology provides data that enables consistent monitoring for timely and proactive implementation of larviciding and adulticiding activities so as to avert increases in indices.

4. Failure to use evidenced-based data in conducting adultidicing (fogging) activities.

If desired mosquito-control targets, such as those set by the World Health Organization, are to be met then the natural behaviour of a particular mosquito specie must be considered. For example, research shows that the Aedes aegyptyi mosquito is diurnal and engages in peak biting activities in the environment approximately two hours after sunrise and several hours before sunset. It is therefore advisable that for rapid reduction in adult mosquito population, adulticiding activities should be done in the same area at dusk and at dawn; wind speed should also be less than 1.6 km/h. Wind speed directly impacts the proper dispersal and effectiveness of insecticides in the atmosphere.

What else is needed for effective mosquito control?

• Mosquito-control programmes require increased investment to strengthen programmatic capacity. The provision of tools and equipment that capture environmental data is mandatory for the success of any mosquito-control programme. Installation and monitoring of rain gauges throughout communities will provide data to identify when increased mosquito control activities are required. Installation and monitoring of light traps and Ovi traps provide useful data to guide mosquito-control activities in areas such as ports of entry. According to International Health Regulations (IHR), a minimum of 400-meter zones around seaports, airports, and ground crossings are to be maintained as a vector-free zone so that the transmission risk of pathogens imported with vectors or reservoirs can be minimised or nullified.

• The use of chemicals, including insecticides, is the first line control for mosquitoes all over the world, however many of these chemicals are known to have damaging effects on the environment. To minimise the need for the use of chemicals in mosquito control, consistent education strategies geared towards environmental sanitation are required. Capturing and using environmental data — such as the sanitary status of a particular community — will identify conditions which are likely to support mosquito-breeding activities in domestic and other settings so that strategies geared towards source reduction can be implemented in a timely manner. Strategies such as community clean-up days implemented ahead of expected seasons of rainfall can prove useful in reducing mosquito indices.

It is a proven fact that much has been done to curtail the incidence and prevalence of mosquito-borne diseases in Jamaica. Amidst these achievements, better use of environmental data as a tool for reducing mosquito-borne diseases can benefit the nation vastly by ensuring more efficient use of resources and reduction of many public health burdens associated with mosquito-borne diseases nationally.

Dr Karlene Atkinson is a public health specialist and lecturer at the School of Public Health, University of Technology, Jamaica.

1 year 7 months ago

Health – Dominican Today

Dengue cases decrease

Santo Domingo—Some 99 municipalities in the country reported a decrease in dengue cases this week compared to those reported the previous week, with the surveillance system capturing 983 new cases of the disease, which has maintained a high demand for medical attention in recent months.

Reduction of cases

Santo Domingo—Some 99 municipalities in the country reported a decrease in dengue cases this week compared to those reported the previous week, with the surveillance system capturing 983 new cases of the disease, which has maintained a high demand for medical attention in recent months.

Reduction of cases

According to reports from the Epidemiology Department of the Ministry of Public Health, during epidemiological week number 48, 983 new dengue cases were reported, showing a reduction in the last four weeks of registration, when the average number of weekly cases exceeded 1,000 reported.

This year, the country is experiencing a dengue epidemic, generating a demand for attention in the emergency and hospitalization areas of clinics and hospitals, especially in Greater Santo Domingo. Epidemic conditions of dengue are also registered in different counties of the region.

1 year 7 months ago

Health, Local

KFF Health News

‘Financial Ruin Is Baked Into the System’: Readers on the Costs of Long-Term Care

Thousands of readers reacted to the articles in the “Dying Broke” series about the financial burden of long-term care in the United States. They offered their assessments for the government and market failures that have drained the lifetime savings of so many American families. And some offered possible solutions.

Thousands of readers reacted to the articles in the “Dying Broke” series about the financial burden of long-term care in the United States. They offered their assessments for the government and market failures that have drained the lifetime savings of so many American families. And some offered possible solutions.

In more than 4,200 comments, readers shared their struggles in caring for spouses, older parents, and grandparents. They expressed anxieties about getting older themselves and needing help to stay at home or in institutions like nursing homes or assisted living facilities.

Many suggested changes to U.S. policy, like expanding the government’s payments for care and allowing more immigrants to stay in the country to help meet the demand for workers. Some even said they would rather end their lives than become a financial burden to their children.

Many readers blamed the predominantly for-profit nature of American medicine and the long-term care industry for depleting the financial resources of older people, leaving the federal-state Medicaid programs to take care of them once they were destitute.

“It is incorrect to say the money isn’t there to pay for elder care,” Jim Castrone, 72, a retired financial controller in Placitas, New Mexico, commented. “It’s there, in the form of profits that accrue to the owners of these facilities.”

“It is a system of wealth transference from the middle class and the poor to the owners of for-profit medical care, including hospitals and the long-term care facilities outlined in this article, underwritten by the government,” he added.

Other readers pointed to insurance policies that, despite limitations, had helped them pay for services. And some relayed their concerns that Americans were not saving enough and were unprepared to take care of themselves as they aged.

What Other Nations Provide

Other countries’ treatment of their older citizens was repeatedly mentioned. Readers contrasted the care they observed older people receiving in foreign countries with the treatment in the United States, which spends less on long-term care as a portion of its gross domestic product than do most wealthy nations.

Marsha Moyer, 75, a retired teaching assistant in Memphis, Tennessee, said she spent 12 years as a caregiver for her parents in San Diego County and an additional six for her husband. While they had advantages many don’t, Moyer said, “it was a long, lonely job, a sad job, an uphill climb.”

By contrast, her sister-in-law’s mother lived to 103 in a “fully funded, lovely elder care home” in Denmark during her last five years. “My sister-in-law didn’t have to choose between her own life, her career, and helping her healthy but very old mother,” Moyer said. “She could have both. I had to choose.”

Birgit Rosenberg, 58, a software developer in Southampton, Pennsylvania, said her mother had end-stage dementia and had been in a nursing home in Germany for more than two years. “The cost for her absolutely excellent care in a cheerful, clean facility is her pittance of Social Security, about $180 a month,” she said. “A friend recently had to put her mother into a nursing home here in the U.S. Twice, when visiting, she has found her mother on the floor in her room, where she had been for who knows how long.”

Brad and Carol Burns moved from Fort Worth, Texas, in 2019 to Chapala, Jalisco, in Mexico, dumping their $650-a-month long-term care policy because care is so much more affordable south of the border. Brad, 63, a retired pharmaceutical researcher, said his mother lived just a few miles away in a memory care facility that costs $2,050 a month, which she can afford with her Social Security payments and an annuity. She is receiving “amazing” care, he said.

“As a reminder, most people in Mexico cannot afford the care we find affordable and that makes me sad,” he said. “But their care for us is amazing, all health care, here, actually. At her home, they address her as Mom or Barbarita, little Barbara.”

Insurance Policies Debated

Many, many readers said they could relate to problems with long-term care insurance policies, and their soaring costs. Some who hold such policies said they provided comfort for a possible worst-case scenario while others castigated insurers for making it difficult to access benefits.

“They really make you work for the money, and you’d better have someone available who can call them and work on the endless and ever-changing paperwork,” said Janet Blanding, 62, a technical writer in Fancy Gap, Virginia.

Derek Sippel, 47, a registered nurse in Naples, Florida, cited the $11,000 monthly cost of his mother’s nursing home care for dementia as the reason he bought a policy. He pays about $195 a month with a lifetime benefit of $350,000. “I may never need to use the benefit[s], but it makes me feel better knowing that I have it if I need it,” he said in his comment. He said he could not make that kind of money by investing on his own.

“It’s the risk you take with any kind of insurance,” he said. “I don’t want to be a burden on anyone.”

Pleas for More Immigrant Workers

One solution that readers proposed was to increase the number of immigrants allowed into the country to help address the chronic shortage of long-term care workers. Larry Cretan, 73, a retired bank executive in Woodside, California, said that over time, his parents had six caretakers who were immigrants. “There is no magic bullet,” he said, “but one obvious step — hello, people — we need more immigrants! Who do you think does most of this work?”

Victoria Raab, 67, a retired copy editor in New York, said that many older Americans must use paid help because their grown children live far away. Her parents and some of their peers rely on immigrants from the Philippines and Eritrea, she said, “working loosely within the margins of labor regulations.”

“These exemplary populations should be able to fill caretaker roles transparently in exchange for citizenship because they are an obvious and invaluable asset to a difficult profession that lacks American workers of their skill and positive cultural attitudes toward the elderly,” Raab said.

Federal Fixes Sought

Other readers called for the federal government to create a comprehensive, national long-term care system, as some other countries have. In the United States, federal and state programs that finance long-term care are mainly available only to the very poor. For middle-class families, sustained subsidies for home care, for example, are fairly nonexistent.

“I am a geriatric nurse practitioner in New York and have seen this story time and time again,” Sarah Romanelli, 31, said. “My patients are shocked when we review the options and its costs. Medicaid can’t be the only option to pay for long-term care. Congress needs to act to establish a better system for middle-class Americans to finance long-term care.”

John Reeder, 76, a retired federal economist in Arlington, Virginia, called for a federal single-payer system “from birth to senior care in which we all pay and profit-making [is] removed.”

Other readers, however, argued that people needed to take more responsibility by preparing for the expense of old age.

Mark Dennen, 69, in West Harwich, Massachusetts, said people should save more rather than expect taxpayers to bail them out. “For too many, the answer is, ‘How can we hide assets and make the government pay?’ That is just another way of saying, ‘How can I make somebody else pay my bills?’” he said, adding, “We don’t need the latest phone/car/clothes, but we will need long-term care. Choices.”

Questioning the Value of Life-Prolonging Procedures

A number of readers condemned the country’s medical culture for pushing expensive surgeries and other procedures that do little to improve the quality of people’s few remaining years.

Thomas Thuene, 60, a consultant in Boston’s Roslindale neighborhood, described how a friend’s mother who had heart failure was repeatedly sent from the elder care facility where she lived to the hospital and back, via ambulance. “There was no arguing with the care facility,” he said. “However, the moment all her money was gone, the facility gently nudged my friend to think of end-of-life care for his mother. It seems the financial ruin is baked into the system.”

Joan Chambers, 69, an architectural draftsperson in Southold, New York, said that during a hospitalization on a cardiac unit she observed many fellow patients “bedridden with empty eyes,” awaiting implants of stents and pacemakers.

“I realized then and there that we are not patients, we are commodities,” she said. “Most of us will die from heart failure. It will take courage for a family member to refuse a ‘simple’ procedure that will keep a loved one’s heart beating for a few more years, but we have to stop this cruelty.

“We have to remember that even though we are grateful to our health care professionals, they are not our friends. They are our employees and we can say no.”

One physician, James Sullivan, 64, in Cataumet, a neighborhood of Bourne, Massachusetts, said he planned to refuse hospitalization and other extraordinary measures if he suffered from dementia. “We spend billions of dollars, and a lot of heartache, treating demented people for pneumonia, urinary tract infections, cancers, things that are going to kill them sooner or later, for no meaningful benefit,” Sullivan said. “I would not want my son to spend his good years, and money, helping to maintain me alive if I don’t even know what’s going on,” he said.

Considering ‘Assisted Dying’

Others went further, declaring they would rather arrange for their own deaths than suffer in greatly diminished capacity. “My long-term care plan is simple,” said Karen Clodfelter, 65, a library assistant in St. Louis. “When the money runs out, I will take myself out of the picture.” Clodfelter said she helped care for her mother until her death at 101. “I’ve seen extreme old age,” she said, “and I’m not interested in going there.”

Some suggested that medically assisted death should be a more widely available option in a country that takes such poor care of its elderly. Meridee Wendell, 76, of Sunnyvale, California, said: “If we can’t manage to provide assisted living to our fellow Americans, could we at least offer assisted dying? At least some of us would see it as a desirable solution.”

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

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1 year 7 months ago

Aging, Health Care Costs, Health Industry, Aid In Dying, california, Dying Broke, Florida, Legislation, Long-Term Care, Massachusetts, Missouri, New Mexico, New York, Pennsylvania, Tennessee, texas, Virginia

KFF Health News

Millions of Dollars Flow From Pharma to Patient Advocacy Groups

Pharma money is all over the place — in universities, companies doing continuing medical education for doctors and in prominent patient advocacy organizations that are household names across America.

Public Citizen, a consumer advocacy nonprofit, reports today that between 2010 and 2022, the drug industry’s main lobbying group and member companies provided at least $6 billion in grants to more than 20,000 organizations. The analysis, provided exclusively to KFF Health News in advance of its release, focused on the Pharmaceutical Research and Manufacturers of America (PhRMA) and 31 drug companies that were members of the trade group as of March.

The money dwarfs industry spending over that time on federal lobbying and campaign contributions to lawmakers. With high drug prices a regular topic of debate in Washington, drug industry grants to patient advocacy groups in particular raises questions about conflicts of interest — including whether organizations that accept the industry’s money shy away from pushing policies the drugmakers oppose, even if patients may benefit. 

“There’s a risk that those entanglements influence the work of those organizations,” said Matthew McCoy, an assistant professor of medical ethics and health policy at the University of Pennsylvania who has studied patient advocacy groups’ influence and transparency. 

He said there’s another important dynamic likely at play, too. Companies aren’t blindly choosing which groups to fund but instead are “probably selecting organizations that are already inclined to see the world, see the policy issues, the way they see it.”

A couple examples you’ll recognize: The American Heart Association received $64.1 million over the 12-year period. The American Cancer Society and its advocacy affiliate, the American Cancer Society Cancer Action Network, together received $23.1 million. 

The question is whether the money affects the heavyweight groups’ advocacy. After the House passed the Inflation Reduction Act in August 2022, the American Cancer Society Cancer Action Network’s statement hailed the bill’s cap on Medicare enrollees’ out-of-pocket costs for prescription drugs and additional tax credits for ACA insurance plans. But the group was silent on a contentious provision giving Medicare the ability to negotiate drug prices with manufacturers. 

Lisa Lacasse, president of the American Cancer Society Cancer Action Network, said in an emailed statement that the organization didn’t take a formal position on Medicare drug negotiation because “the policy’s impact on patient access to and affordability of cancer treatments was unclear.” In contrast, the Part D out-of-pocket cap “has evidence-based patient benefit.” 

  • “ACS CAN’s only constituents are cancer patients, survivors, and their loved ones nationwide. ACS CAN’s policy agenda is driven entirely by evidence with the single purpose of achieving our mission to end cancer as we know it, for everyone,” she added. “Contributions to the organization do not influence policy decisions or positions.”

The American Heart Association similarly has touted its support of the three-year extension of enhanced Obamacare tax credits in the IRA, but was silent on drug price negotiation. “We have strict standards in place to monitor relationships with industry and protect against conflicts of interest,” Steve Weiss, a spokesperson for the group, said in an emailed statement. “These funds in no way influence our advocacy, programs or science.”

  • We engage with different organizations who have a wide array of health care opinions and priorities,” Alex Schriver, senior vice president of public affairs at PhRMA, said in an emailed statement. “We may not agree on every issue, but we believe engagement and dialogue is important to promoting a health care policy environment that supports innovation, a highly-skilled workforce and access to lifesaving medicines.”

While the patient groups’ primary mission is to advocate for people with particular diseases, including by boosting funding for research, their work in Washington often bolsters that of pharmaceutical companies whose drugs their patients rely upon. At the same time, the story isn’t always black and white, and just because a group gets money doesn’t automatically make them a “pharma lackey,” said Mike Tanglis, research director at Public Citizen. “It’s not so clean cut,” McCoy added.

The American Diabetes Association received $26.4 million from the drug industry —  yet the group supported allowing Medicare to negotiate prescription drug prices. Multiple drug companies have sued to stop the program. 

Francisco Prieto, chair of the American Diabetes Association’s national advocacy committee, said in a statement that support from its corporate and other partners allows the group to provide resources about diabetes to health care personnel as well as patients and their caregivers. 

“Our partners do not influence our business or policy decisions, which are made solely based on our mission and what is in the best interest of patients around the world,” he said.

Many groups receiving grants do criticize high drug prices generally or highlight patients’ difficulties in affording care. But, “specifically calling out pharma companies doesn’t seem to be a huge priority for them,” Tanglis said. 

It isn’t always obvious which groups drug companies are paying. Congress in 2010 enacted the Physician Payments Sunshine Act, a law that required payments to physicians from drug and medical device makers to be registered on a public website. But patient groups were not addressed in the bill. Drug companies’ payments to patient groups can be — but aren’t always — included in annual filings to the IRS or in charitable giving reports.

The American Heart Association in its 2022 annual report lists contributions from corporations, foundations and others. The American Diabetes Association in its latest annual report lists corporate sponsors and ranges for the amounts they give, but not precise dollar figures. Similarly, the American Cancer Society’s most recent report names corporate sponsors giving more than $1 million, but exact amounts aren’t disclosed.

McCoy believes there should be “some kind of mandated transparency across the board” for payments and that patient groups should openly answer questions about steps they take to make sure the funding doesn’t influence their decisions.

“Those are all great things that patient advocacy groups can and should be doing,” McCoy said.

This article is not available for syndication due to republishing restrictions. If you have questions about the availability of this or other content for republication, please contact NewsWeb@kff.org.

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

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This story can be republished for free (details).

1 year 7 months ago

Health Industry, Pharmaceuticals, The Health 202

Medical News, Health News Latest, Medical News Today - Medical Dialogues |

Dual ICMR Recognition: Amrita Hospital, Kochi, Bags now Centre of Excellence in Groundbreaking Snakebite and Paediatric Cardiac Research

Kochi: Amrita Hospital, Kochi, has earned dual recognition from the Indian Council of Medical Research (ICMR) for its groundbreaking contributions to venomous snakebite and pediatric cardiac research.

This significant acknowledgment establishes the hospital, as a Centre of Excellence in both domains, reinforcing its position as a leader in medical research and a frontrunner in addressing critical healthcare challenges.

Also Read:Kerala's First Advanced Centre for Neuro Endoscopy Surgeries inaugurated at Amrita Hospital, Kochi

The designation of the Centre of Excellence for snakebite treatment by ICMR signifies the creation of the first-of-its-kind centre in the entire country. This distinction is a testament to the team's exceptional work in therapeutic, preventative, capacity-building, awareness creation, and research aspects related to snakebite.

The distinguished team includes Dr. Jaideep Menon, Dr. Bipin Nair, V V Pillay, Gireesh Kumar, T P Sreekrishnan, Sabarish B. Nair, Muralidharan V, and Aravind MS.

Snakebite a Neglected Tropical Disease (NTD), is predominantly a rural issue affecting millions across the globe in the Tropics and sub-Tropics, most commonly occupational or accidental. India shares a significant burden, with an estimated 58,000 deaths annually, constituting over half of the global toll. WHO data reveals 4.5 to 5.4 million snakebites yearly, leading to 1.8 to 2.7 million envenomings, with 81,000 to 138,000 victims succumbing to complications and 400,000 developing permanent disabilities. In September 2022, the Union Ministry of Health and Family Welfare (MoHFW) initiated a national program for snakebite envenoming prevention and control.

Dr. Jaideep Menon, Professor, Adult Cardiology and Public Health, Amrita Hospital, Kochi, expressing gratitude for the ICMR recognition, stated, "Over 70% of snakebite cases impact males aged 20 to 60, causing severe socio-economic consequences, often resulting in the loss of the family's primary breadwinner. This distinction motivated our team to intensify our comprehensive approach, including awareness creation, capacity building, and essential research.

The Collaborative Centre of Excellence aims to address various aspects related to snakebite envenoming, including developing information, education, and communication (IEC) materials, conducting high-priority research, networking with stakeholders, and providing policy inputs to reduce mortality and morbidity associated with this neglected public health concern.’’

The Collaborative Centre of Excellence aims to research snakebites, build a comprehensive repository on snakes, venom, and treatment, identify mitigation hotspots, collaborate with institutions, conduct awareness-raising research, and contribute to the 2030 SDG target, with a focus on enhancing public health capacity and advocacy. The CCoE aims to generate evidence necessary for laying out the National Program on snakebite in India.

Simultaneously, Amrita Hospital's Pediatric Heart Program, Kochi also, received the prestigious Centre of Excellence award from ICMR, recognizing its exceptional contributions to pediatric cardiac research.

This accolade, granted through a rigorous nationwide application process for collaborating centers of excellence, highlights the program's outstanding track record in high-quality research, publications, innovations, and mentorship.

Established in 1998, Amrita Hospital's Pediatric Heart Program demonstrates enduring commitment through groundbreaking research, addressing vital questions in delivering pediatric cardiac care in resource-limited settings.

The program's legacy includes developing cost-effective strategies for managing congenital heart defects, publishing in leading international journals, and conducting impactful community-based studies on pediatric heart disease. Over the years, the program's dedicated research facility has overseen numerous grant-funded projects, resulting in a rich portfolio of over 200 published papers, fostering a culture of research among trainees who regularly contribute to esteemed international journals.

Dr. R. Krishna Kumar, Clinical Professor and Head of Pediatric Cardiology at Amrita Hospital, Kochi, along with Dr. Mahesh, Clinical Professor of Pediatric Cardiology, expressed, "Accepting the prestigious Centre of Excellence award from DG ICMR for our Pediatric Heart Program at Amrita Hospital fills us with great pride.

This recognition underscores our steadfast commitment to advancing pediatric cardiac research. Our dedicated team consistently engages in high-quality research, leading to innovations and impactful publications. This award stands as a testament to our continuous efforts and inspires us to persist in our journey of excellence in pediatric cardiac care."

The official ceremonies unfolded at the ICMR headquarters in New Delhi, where Director-General Rajeev Behl presented plaques to the distinguished teams. With these two awards, the Centres are actively working on developing pan-India solutions to address these critical health challenges.

Also Read:Amrita Hospital hosts India's 1st educational course of International Stereotactic Radiosurgery Society

1 year 7 months ago

State News,News,Health news,Kerala,Hospital & Diagnostics,Doctor News,Latest Health News,Recent Health News

KFF Health News

KFF Health News' 'What the Health?': Abortion and SCOTUS, Together Again

The Host

Julie Rovner
KFF Health News


@jrovner


Read Julie's stories.

The Host

Julie Rovner
KFF Health News


@jrovner


Read Julie's stories.

Julie Rovner is chief Washington correspondent and host of KFF Health News’ weekly health policy news podcast, “What the Health?” A noted expert on health policy issues, Julie is the author of the critically praised reference book “Health Care Politics and Policy A to Z,” now in its third edition.

The Supreme Court this week agreed to hear a case that could further restrict abortion — even in states where it remains legal. The case to determine the fate of the abortion pill mifepristone is the first major abortion case to come before the court since its overturn of Roe v. Wade in 2022. It could also set a precedent for judges to second-guess scientific rulings by the FDA.

Meanwhile, legislation is finally moving in the House and Senate to renew a long list of health programs that technically expired at the end of the last fiscal year, on Sept. 30. But the bills to fund community health centers and build on programs to fight the opioid epidemic are unlikely to become law until January, at the soonest.

This week’s panelists are Julie Rovner of KFF Health News, Riley Griffin of Bloomberg News, Alice Miranda Ollstein of Politico, and Lauren Weber of The Washington Post.

Panelists

Riley Griffin
Bloomberg


@rileyraygriffin


Read Riley's stories

Alice Miranda Ollstein
Politico


@AliceOllstein


Read Alice's stories

Lauren Weber
The Washington Post


@LaurenWeberHP


Read Lauren's stories

Among the takeaways from this week’s episode:

  • The Supreme Court will consider a case challenging access to mifepristone, opting to review FDA decisions in recent years governing the loosening some requirements for distribution and use of the so-called abortion pill — such as the agency’s call allowing pregnant people to obtain the drug without a doctor’s visit. While the drug’s overall approval is not in question in this case, the drug industry argues undermining the FDA’s authority could open the floodgates for challenges to other pharmaceuticals and have a chilling effect on drug development.
  • Legal experts say the Texas high court’s ruling blocking the abortion of a pregnant woman whose fetus has a fatal condition calls into question whether doctors are able to identify any medically necessary circumstance under existing legal exceptions. And, in other court news, the Supreme Court will let stand a Washington state law banning conversion therapy.
  • On Capitol Hill, lawmakers are bundling an assortment of bipartisan, generally unrelated health measures so they can be approved, possibly as part of a government spending package in January. But can this Congress — which has proved unproductive even by recent standards — finish its work in a presidential election year?
  • One piece of legislation under consideration would address the opioid epidemic, renewing grants for state efforts to prevent and treat opioid use disorder. The epidemic has taken a toll, but it is not the only problem contributing to a troubling drop in U.S. life expectancy.
  • And cyberattacks are on the upswing in health care, with new revelations about an attack that targeted the Department of Health and Human Services at the onset of the pandemic.

Also this week, Rovner interviews University of Maryland professor and social media superstar Jen Golbeck about her new book, “The Purest Bond,” which lays out the science of the human-canine relationship.

Plus, for “extra credit,” the panelists suggest health policy stories they read this week that they think you should read, too:

Julie Rovner: The Washington Post’s “They Watched Their Husbands Win the Heisman — Then Lost Them to CTE,” by Kent Babb.

Alice Miranda Ollstein: Politico’s “A Deadly Delivery Highlights ‘Falsified’ Heat Records at USPS,” by Ariel Wittenberg.

Lauren Weber: The Washington Post’s “Applesauce Lead Cases in Kids Surge Amid Questions on FDA Oversight,” by Amanda Morris, Teddy Amenabar, Laura Reiley, and Jenna Portnoy.

Riley Griffin: Bloomberg News’ “The Next Blockbuster Drug Might Be Made in Space,” by Robert Langreth.

Also mentioned in this week’s episode:

click to open the transcript

Transcript: Abortion and SCOTUS, Together Again

KFF Health News’ ‘What the Health?’Episode Title: Abortion and SCOTUS, Together AgainEpisode Number: 326Published: Dec. 14, 2023

[Editor’s note: This transcript was generated using both transcription software and a human’s light touch. It has been edited for style and clarity.]

Julie Rovner: Hello, and welcome back to “What the Health?” I’m Julie Rovner, chief Washington correspondent for KFF Health News, and I’m joined by some of the best and smartest health reporters in Washington. We’re taping this week on Thursday, Dec. 14, at 10 a.m. As always, news happens fast, and things might’ve changed by the time you hear this. So here we go. We are joined today via video conference by Alice Miranda Ollstein of Politico.

Alice Miranda Ollstein: Good morning.

Rovner: Lauren Weber of The Washington Post.

Lauren Weber: Hello, hello.

Rovner: And we welcome to the podcast for the first time Riley Griffin of Bloomberg News.

Riley Griffin: Thanks for having me.

Rovner: Later in this episode, we’ll have my interview with University of Maryland professor Jen Golbeck, who is probably better known to anyone on social media as “GR Mom,” the woman who takes in half a dozen special-needs golden retrievers at a time. She’s co-author of a new book called “The Purest Bond” that explains why our love for dogs is not just all in our heads. But first, this week’s news.

We will start with abortion this week. In news, Alice, that you anticipated last week, the Supreme Court has decided to hear a case out of Texas regarding the abortion pill mifepristone. Depending on how the court rules, it could make abortion less available even in states where it remains legal. But Alice, this might not be as consequential as it looks at first blush because they didn’t take the case that could have impacted the overall approval of the drug, right?

Ollstein: That’s right. So they’re basically taking up what the 5th Circuit decided, not what the district court decided. The district court, as we remember very dramatically, decided that FDA approval of mifepristone decades ago was done incorrectly and would have moved to effectively ban the drug nationwide. What’s at issue before the Supreme Court are subsequent FDA decisions to make the pill more easily accessible, but those are really important and sweeping. I mean, I feel like the mail delivery piece is getting a lot of attention, but it’s not just that.

These are decisions that, one, approved a generic version of the pill, which made it cheaper and more accessible all over the country. It expanded its use from just the first seven weeks of pregnancy to the first 10 weeks of pregnancy. Those crucial weeks are when a lot of people realize they’re pregnant and make a decision about that. And more recently, allowing retail pharmacies to dispense the pills and, crucially, not requiring an in-person doctor visit to obtain them.

So the companies that make the pills say that if the Supreme Court were to side with the groups challenging these rules, it would be a de facto ban, at least temporarily, while they have to go through relabeling and retooling and everything. And that could take a while. So I think while abortion rights groups are celebrating that the overall approval of the pills is not in question, this is still very, very consequential, and it’s going to be decided just months before the presidential election, keeping this really front and center in people’s minds.

Rovner: Just to confirm though, the Supreme Court has already weighed in and put even what the 5th Circuit did on hold, right?

Ollstein: Yes.

Rovner: So nothing has changed at the moment from what’s originally available.

Ollstein: That’s right. And so in states that have their own bans, the bills are still banned. In states where they’re protected, they’re still protected, and that will continue until the high court hears and rules on the case.

Rovner: But even though, I mean, the court is not going to take up the case where the lower-court judge said that the FDA shouldn’t have approved this in the first place, this could still be the Supreme Court basically overruling FDA’s judgment about what’s safe and effective, which could have big implications for drugs way beyond mifepristone, right?

Ollstein: That’s what the companies that make the pills and other unrelated pharmaceutical companies have been arguing. They say that this could open the floodgates for anyone with a grievance against any drug to try to challenge it. People are worried about contraception. People are worried about covid shots. Anything that’s generated any level of pushback and controversy, that would greenlight this strategy for them.

And the pharmaceutical industry has also argued that it could put a chilling effect on companies even submitting new drugs for approval, saying, if they don’t have the confidence that a court could come in later and yank away the approval, why would they feel confident in putting this out on the market? So this has the potential to be really disruptive. And I would note it comes at a time when the Supreme Court is overall really questioning deference to federal agency decisions across the board, anything from the Commerce Department to … there was a case about phishing regulations. And so, overall, it’s this “war on the administrative state” effort and this is definitely a piece of it, and it could affect health care in a lot of ways.

Rovner: Riley, you watch the drug industry. First, they were staying out of it, and then they finally decided, oh, we should get a little bit exercise because this could be important. Where are they these days?

Griffin: I think what’s been so novel for me situated here in D.C. is to watch industry lobby conservatives on this agenda. To say, this is about business interests. And if you break this house of cards, what else is going to come crashing down? So Alice made that point, and it’s a really important one. The implications here are far-reaching. And in questioning the FDA’s authority in this space, you are really going so much further, and it calls into question other drugs.

Rovner: So great, we’ll have something to talk about for weeks and weeks to come. Well, still in Texas — why does it seem that all the abortion news comes out of Texas? Last week we talked about Kate Cox, a 31-year-old mom of two, whose fetus was diagnosed at 20 weeks with a birth defect incompatible with life.

When we left off taping last Thursday morning, her lawyers were asking a Texas state judge for permission for her to have an abortion because her doctor said continuing the pregnancy could threaten her health and/or her ability to have more children in the future. Alice, a whole bunch of things happened after that. Catch us up.

Ollstein: People are really seizing on this case because it really calls the question on a lot of the assumptions of our post-Roe legal and health care landscape. And so a lower court ruled in her favor and said she should be able to get an abortion to protect her health and her ability to have another child. They said that the state should be barred from bringing criminal charges against the doctor performing the procedure. So that was all set to go forward.

And then the Texas Attorney General Ken Paxton, who recently survived an impeachment attempt, I should note, moved to intervene and moved to ask the Texas Supreme Court to stop this abortion from happening. He argued that the woman should not qualify for a medical exemption, and the Texas Supreme Court put a hold on the lower-court ruling and said it needed a little more time to think about it. And then they came back and ruled against the woman and said she should not be allowed to get an abortion. But it was moot in terms of her specific situation because of the threats to her health. She had already been to the emergency room several times at this point, and so she decided to go out of state for the procedure.

When I wrote about this, I tried to look into what are the bigger implications here. And a legal expert said something that really struck me, which is that the entire Dobbs premise is that you could ban so-called elective abortions, but maintain access to medically necessary ones. Sometimes they’re called therapeutic abortions. There’s a lot of weird terminology. And this really calls that question, can you always distinguish between those two?

Who’s to say? Here, the doctor’s interpretation of which was which clashed with the state’s interpretation of which was which. A lot of states have these so-called “life of the mother” exemptions, and this really shows that they are very difficult to use in practice.

Rovner: I’ve covered this for so many years at the federal level with little wording changes to the Hyde Amendment, and the big fight has always been between exceptions for the life of the mother and for the health of the mother. And the anti-abortion movement has always said, you can’t have a health exception because that would include mental health and it would just include anyone who said she doesn’t want to be pregnant.

So the phrase is always “It’s a loophole you can drive a truck through.” But then you get to these cases where it clearly is women whose water breaks at 20 weeks, it will eventually be life-threatening, but is immediately health-threatening. But a lot of these states don’t have health exceptions because they say that they could be used too broadly, and that’s kind of where they get stuck, right?

Weber: Yeah. I just wanted to chime in and say that I think what’s interesting about this case is this is the first time I’ve heard a lot from folks that aren’t in the media at all, don’t read the media every day, don’t see the flood of stories that this podcast group and folks, probably many of the listeners to this podcast, have seen about abortion coverage. It’s the first time I got a wave of phone calls being like, “Hey, can you explain this to me? What does this mean?” So I think that this story out of Texas, this reality, this lawsuit, has broken through to the rest of the country.

I mean, granted, this is an anecdotal sample size of my family and friends that live in the heart of the country, but I do think this has broken through in a way that many of the other stories that we’ve all written here have not. And so I’m very curious to see how this continues to play out because I do think this is gaining a lot more awareness with these lawsuits. We have this one, and then I know there’s one in Kentucky that I think we’ll see play out in the next couple weeks and months, obviously.

Rovner: Yeah, and I think one of the things that’s really important about this is that we know her name and we know what she looks like because she’s been brave enough to come forward in the middle of this medical crisis and allow them to use her name and do TV interviews. And Alice, I interrupted you.

Ollstein: Oh, yes. A couple things. We haven’t mentioned that this was a non-viable pregnancy. Her fetus was diagnosed with a almost certainly fatal condition. So I think that’s another key piece of it. Other states have an exemption for fetal diagnoses like this where someone can get an abortion. Texas does not. And I talked to some Texas anti-abortion groups who were insistent that she should not be granted an exception and that the “compassionate” thing to do would be to force her to give birth and then watch the child die and mourn it. They were very explicit about that.

And so I think that is also capturing a lot of people’s attention, like Lauren was saying, where they’re fighting for a potential life that is very potential at this point. And you’re hearing a lot of rhetoric from conservatives right now that are insisting that allowing exemption for fatal fetal conditions is akin to eugenics. They say that these fetuses should be given every chance at life, even if that life is very brief and sometimes painful. So I think this is a debate we’ll continue to see play out.

Rovner: Yeah, I was surprised. I mean, Kellyanne Conway, of all people, who’s not just the former Trump aide, a prominent Republican pollster, actually had a tweet this week that suggested this is not great for Republicans. What’s happening to this woman? The fact that it’s so public. Riley, you wanted to say something?

Griffin: Yeah, just another point Alice mentioned, “this potential life,” but the attorneys have also mentioned the potential for future lives … that this woman, it’s not just her health being impacted, but it also could decrease her ability to have children in the future, which is another part of this story that I think is really tugging at people’s heartstrings. And just that the ruling came hours after she made the announcement that she’d left the state to get the procedure. I mean, all of these things combined make for such a poignant story.

And I want to bring in some research that has also recently been published, which suggests she’s not alone. Nearly 1 in 5 people seeking an abortion have traveled out of state, according to the Guttmacher Institute, citing data from the first half of 2023. And experts are saying this is probably an underestimate. And when you do get to those states in places where abortion remains legal, wait times are increasingly long.

So there are so many dynamics at play. It’s not just the states where access is limited and we’re seeing these very difficult rulings come down, but what are the consequences in the places where access remains available? But that flood of folks trying to get these procedures have to make that travel. Sorry, I jumbled my words there, but you understand what I’m saying, or I can try again.

Rovner: The other piece of that, if you play that all the way out, where women are having to travel and they often have other kids, so they have to get someone to watch their kids and they have to get time off of work, and they have trouble getting appointments in other states, and that means that these abortions are happening later in pregnancy, which is, I know, not what the anti-abortion movement wants. And also the later in pregnancy you get, the more risks there are and the more expensive the whole thing gets.

So it’s just the whole thing is piling on each other. But I think, Riley, something you said that I think I keep highlighting and want to keep highlighting, most of the women we’ve been talking about individually are women who got pregnant because they wanted to have a baby. These are not women who weren’t using birth control and like, oops, I got pregnant. Kate Cox wants to have more children. This was a very wanted pregnancy. … I think one of the things we’re discovering through all of this is that more pregnancies go wrong than people realize. It’s just that when pregnancies go wrong, people tend not to want to talk about it. It’s painful and awful, and it’s not like having your appendix out. So I think we’re kind of, as a population, discovering that pregnancy is fairly fraught. For every baby that’s born happy and healthy, there are a lot of pregnancies that just don’t work the way they’re supposed to.

Ollstein: And I also have seen a lot of chatter saying, “This is the new frontier. We’re going to see this wave of individual women suing for the right to have an abortion.” And I don’t think that’s true. Kate Cox’s lawyers don’t think that’s true. Most women in this circumstance can’t do this or are not willing to be the public face of a lawsuit and get all kinds of threats and harassment.

And a lot of people aren’t able physically to wait for a court to rule. Even Kate Cox wasn’t. And so the idea that there’s going to be so many people who are actively pregnant and seeking an abortion and have the resources to find an attorney willing to represent them and are willing to go through this, I think I’m hearing that that is not likely at all, that this is somewhat of an outlier.

Rovner: While we were talking about asking permission for courts, the Supreme Court this week declined to review a challenge to a Washington state law that banned so-called conversion therapy. I’m still having trouble wrapping my head around this because it’s like a quadruple negative, but what is conversion therapy and where are we now that the appeals court ruling is being allowed to stand?

Weber: I think a lot of people don’t realize this, but there was actually a report that just came out from The Trevor Project. Conversion therapy is a process in which people try to, they call it, convert LGBTQ folks to have heterosexual relationships, and there could be a wide array of what that means. It involves sometimes psychological therapy, sometimes physical therapy, all kinds of things. Many, many states have banned this because science has shown it is not an effective treatment and can lead to mental health effects.

But I think why this ruling is important is that, as I was saying, The Trevor Project has identified there’s over 1,300 practitioners of conversion therapies across the country. Even though this is banned in so many states, this is a practice that goes on and on and on, despite what seems to be a lot of negative health impacts of it. So the fact that the Supreme Court decided not to take this up at all is considered very much a win for the LGBTQ community, especially considering the fact that this does still go on in many, many states.

Rovner: At least … that’s one thing that’s off the table, at least for the very moment. Well, let us go back to Capitol Hill, where lawmakers are actually passing stuff, albeit so late in the session that these policies are unlikely to make it over the finish line until 2024.

The House Monday night passed a bill that includes a bunch of things we’ve been talking about all year: site-neutral payments in Medicare to prevent hospital outpatient departments from charging multiples more to Medicare than non-hospital affiliated facilities; banning some pricing practices by pharmacy benefit managers; clarifying and extending some price transparency rules for hospitals and insurers, particularly those not making their prices public even though it is now required by law; funding community health centers; and stopping some scheduled cuts to hospitals that serve a high proportion of low-income patients.

Yes, that’s a whole lot of things that don’t necessarily go together, but this is how Congress works. All of these things were supposed to happen before the start of the new fiscal year, Oct. 1. Now, let me check, it is the second week of December. These are pretty bipartisan policies, most of them. What the heck took them until December to get this through?

Ollstein: This has been, even by Congress’ standards, a historically unproductive Congress. We spent a lot of the year battling over who should be the House speaker, for instance. That took up a lot of time. They took a really long summer recess, and there’s been all kinds of back and forth over just keeping the government funded. So that has not left a lot of room for basic policymaking. And there’s the fear that heading into next year — a lot of this stuff is getting punted into next year — that only gets harder in an election year. They’re in session less time. There’s less of an incentive to compromise. People are really retreating into their corners. And so it’s not a great outlook, even for things that really are popular on both sides of the aisle.

I will say, on the site-neutral payments piece, that’s been a long-time goal for a lot of people. And what’s being debated now is seen by some as inadequate, way not enough. It’s only a narrow set of drugs within Medicare. People would like this to be implemented way more broadly.

But you also have the hospital industry really mobilizing against it and saying, “You know all those rural hospitals that are closing down and going out of business? That’s going to get worse if you do this.” And as we know, hospitals are often the biggest employer in a lot of congressional districts, and so that could make this hard to pass as well.

Rovner: The same thing with the PBM [pharmacy benefit manager] reforms, and you’ve got the drug industry and you’ve got the hospital industry. So even though these things are “bipartisan,” that doesn’t mean that there isn’t plenty of opposition out there, which I guess kind of answers my question of why this took so long. I imagine we expect this — now that it’s in a package — to go on the next government funding bill, which should be in January, right? That’s what we’re looking for?

Weber: Yes, it should go in the next government possible spending bill, but who knows? Are we headed towards another shutdown when that happens? I mean, we’ll have to see. And I just want to echo what Alice said. I mean, not doing a lot of lawmaking this year does have real consequences. I mean, when we talk about these site-neutral payments — I’ll never forget when I was at KHN [KFF Health News], I wrote a story about a seamstress who had rheumatoid arthritis, and she went to the same doctor’s office every time to get arthritis shots. Very normal treatment, right? Her doctor’s office moved up one floor and her bill went up 10 times. Her shots went from $30 to $300 because they were then considered an in-hospital facility. So when we talk about things like site-neutral payments, which are jargony words, they disguise what happens to everyday Americans and the actual cost — literal cost, physical and emotional and financial — of legislation like this not making it through.

Rovner: And I think the biggest irony is that when you look at public opinion polls, Democrats and Republicans are so divided on so many things, but one of the things that they are not divided on at all is that health care costs too much and the Congress should be doing things to make health care cost less. So these are things that, if they can get them over the finish line, would actually be popular.

Well, speaking of things Congress was supposed to do before the start of the fiscal year, Riley, you’re watching the progress of another bill we’ve been following, the SUPPORT [Substance Use Disorder Prevention that Promotes Opioid Recovery and Treatment for Patients and Communities] Act, that authorized programs to fight the opioid epidemic. Remember the opioid epidemic? What’s the status of that bill?

Griffin: Yeah, great question. So more than two months ago, provisions from a major 2018 opioid law, the SUPPORT Act, which provides grants for states to pay prevention, treatment, and recovery services for people with opioid use disorders, expired. But on Tuesday, the House and Senate HELP Committee advanced that legislation in an effort to expand treatment for opioid use disorder amid the ongoing epidemic. And, as you’d mentioned, this is known as the Support for Patients and Communities Reauthorization Act and the Modernizing Opioid Treatment Access Act.

And we saw the House overwhelmingly vote to reauthorize the law. And, meanwhile, the Senate HELP Committee also approved its version of the bill, setting up consideration by the full Senate and likely enactment of a new law quite soon. Sen. Bernie Sanders of Vermont said that passing this $4.3 billion piece of legislation to reauthorize and expand the SUPPORT Act would be a huge success and will do a lot to increase the number of substance abuse counselors and mental health professionals.

Rovner: But again, not likely before the end of the year, this bill that should have been done before Oct. 1.

Griffin: Precisely. But again, also a place where you see that bipartisan support. I mean, the opioid epidemic is something that is coming up on the debate stage. Fentanyl is a buzzword that is being used by Democrats and Republicans alike. And not just to talk about the state of affairs here in the United States, where more than 100,000 people die every year of overdose-related deaths, but also to talk about immigration reform and China, right? These topics have all become a swirling part of the discourse on the opioid epidemic, and it’s something to watch going into the 2024 election.

Rovner: Yes. Something else that is linked to the whole opioid epidemic is this concern about life expectancy. We’ve had some new statistics on life expectancy, which is creeping back up now that deaths from covid are falling off, but not as fast as in many other industrialized countries. Women’s life expectancy is still substantially longer than men’s. What is up with this and what is holding the U.S. back? Why is our life expectancy still so much worse than people across the pond?

Weber: I think there’s a lot of things at play in the U.S. and a lot of it has to do … right now, we’re seeing it creep up because of the covid numbers. But what covid exposed was an absolute failure of primary care across the United States, an absolute failure of public health, an absolute failure to confront the fact that the vast majority of the reason that our life expectancy is so much worse than other countries is because of our chronic disease problem that is not getting dealt with.

And frankly, post-covid, it’s not like we’ve seen some sort of ginormous wake-up call overhaul either. I mean, this is the reality that we’re continuing to live in. So while it is heartening to see that the life expectancy numbers are changing a little bit because the covid death rates have gone down, I think the U.S. still has to grapple with the fact that we live in a country that is not addressing these issues. And I mean, I’ve talked about this on this podcast, but to reiterate again, politics does play into this.

As you see, there are … red states’ life expectancies are typically lower than blue states’ life expectancies. And that’s due in part to the fact that in the 1980s, Reagan and Congress allowed the states to decide how they were going to spend their public health and safety-net dollars in different ways, and we’ve seen that play out in this grand experiment over the last couple decades. And, again, doesn’t seem to be much reckoning with that either. So I think these life expectancy trends, where the U.S. lags behind other countries, are going to continue.

Rovner: Yeah, I wanted to actually call out a piece that Paul Starr at Princeton wrote about these red state-blue state differences because a lot of them we had talked about. Red states had earlier death rates because of the opioid epidemic and fentanyl and these deaths of despair.

But, actually, what the research that Paul Starr looked at was more what you’re saying, Lauren, which is that the states that enrolled children in Medicaid earlier are having better outcomes now, 30, 40, 50 years later, than the states that didn’t. And, also, the states that had restrictive gun laws are having longer life expectancies than states that didn’t. Riley, you’re nodding your head.

Griffin: It’s an amazingly unique American paradox to see greater spending on health care and yet shorter lives compared to other countries. Wealthy nations which spend half per person on health care compared to the United States are seeing their citizens outlive Americans by an average of more than five years. I mean, that data when you put it together is just so jarring. And it, as Lauren has been saying, has been cementing itself before the covid pandemic, which obviously had such a devastating toll.

But as we start to see that trend shift, where in 2022 life expectancy at birth was 77.5 years compared to 76.4 the year prior, that change is largely due to a decrease in covid deaths. We’re still seeing deaths from flu, pneumonia, fetal and infant conditions continue to rise. So the infectious disease front doesn’t look good in other spaces. And as you mentioned, Lauren, these chronic diseases that really set the U.S. apart from its peers, GDP-size-wise, is just so jarring.

Rovner: Finally, this week, because there isn’t already enough for us to worry about with the health system, cyberattacks appear on the upswing. Every week we hear about hospital IT systems literally being held for ransom and hacks into databases with our very most sensitive personal information, like 23andMe. Riley, you have a story about a hack at HHS [the Department of Health and Human Services] that was more serious than we thought.

Griffin: Yeah, thank you for allowing me to speak about this story. So my colleague Jordan Robertson and I investigated a cyberattack that hit HHS at the very outset of the pandemic. And at the time, we found that it was downplayed by department leadership. So only years later, it’s three-plus years down the road, we’ve learned through on-record interviews and other discussions that it was actually quite an unusual and rather concerning case. Some of the officials described the attack as an attempt by a nation-state to break into the department managing the U.S. covid response just as HHS’ IT staff were temporarily loosening security to its more than 80,000 employees so that they could log in remotely. They used a common technique, which is called a DDoS, or a distributed denial-of-service attack, where hackers disrupt a computer network by flooding it with traffic.

Now, typically when people think of this kind of attack, it’s meant to overwhelm and then shut down the system. But what we learned through interviews with these officials is that it was more of an act of espionage. Rather than shutting down the system, it was intended to map HHS’ network. So a pretty concerning story to say the least. And another novel part of this is that the officials, the Chief Information Officer Jose Arrieta and Chief Information Security Officer Janet Vogel, said the attack began ramping up as early as October of 2019.

So a lot of strange pieces at play. Those two officials attribute the attack to China, though HHS has said it did not come to that conclusion. And the Office of Inspector General complicated the picture further by saying that they actually found it was connected to a person, an entity in Ukraine. So not all the questions are yet answered, but I think the takeaway from this story is that when a cyberattack hits, not everything is as it seems.

Rovner: Yeah, OK. All right, one more thing that we will consider on our watch list. All right, well, that is this week’s news. Now we will play my interview with Jen Golbeck about her book on the science of dog love, and then we’ll come back and do our extra credits.

I am so excited to welcome to the podcast Jen Golbeck, a computer science professor at the University of Maryland who studies the internet for a living. She does serious research about some pretty grim corners of the online community, which we will talk about in a moment. But she’s probably better known on social media as “GR Mom,” head wrangler of The Golden Ratio media universe that brings the joy of her ever-changing pack of special-needs golden retrievers to her hundreds of thousands of followers every day, myself included, I have to say. Jen, thanks so much for being here.

Jen Golbeck: My pleasure. Thank you.

Rovner: So we’ll get to your new book, “The Purest Bond,” in a moment. But first, I know you spent a lot of time tracking the behavior of some of the most unpleasant and reprehensible people online. Is that part of why you started your little social media corner of happiness?

Golbeck: Yes. So I am very on social media. I’m a computer scientist by training. And after [President Donald] Trump got elected, everybody was angry online. Regardless of who you voted for, everyone was angry. And I just found myself needing an escape from that and I couldn’t really find it. And at the time, I had four golden retrievers and I was like, you know what? That can’t get much happier, so let’s just start putting pictures of them up.

So it was as much therapy for me as anything else, but it really ended up resonating with people and bringing together this wonderful community of people. And anybody who’s not nice, we block and keep them out of there. Things have not necessarily gotten better, but different, since 2016, 2017, and people still need that escape, including me. So yeah, it’s been a real balm in contrast to my regular research work to do that.

Rovner: Which is, you should say, looking at how hate spreads online. Is that a lot of what you do?

Golbeck: That’s pretty close, yeah. I think my technical term I use is malicious online behaviors. So we look at hate speech and extremism, misinformation, conspiracy theories, all that kind of stuff. So dogs are a really nice antidote to that.

Rovner: So with all the terrible things that go on online, I’m fascinated by the devotion of little groups of people who share interests and love to interact with each other. I still obviously have to be on Twitter, or whatever it’s called now, for my job. And I remember when I first met Matt Nelson, actually at your live show, who’s the creator of WeRateDogs (dogrates), I thanked him for making the online hellscape just a little bit less hellish. Do we underestimate how much online relationships can benefit people as much as cause mischief?

Golbeck: Yeah. The research on this is so interesting. Because since Facebook became a thing, we’ve been really interested in what’s the impact, the psychological impact, of social media? And the answer is always it’s super mixed, which is a kind of an academic cop-out answer, but totally true. There’s all kinds of ways that, obviously, the internet can harm people, and we see that now especially with Instagram and girls with eating disorders and body image issues. We know that generally people who spend a lot of time on social media are less happy than people who don’t.

So there are unquestionably some negative impacts, but it’s a little bit easy to forget, and some people weren’t even alive, when we didn’t have access to communities online and how profoundly isolating life could be and how difficult it was to get access to anything, especially social support. So now you can be in a very rural isolated space and very different from what the social mores of your community would dictate you should be. And that’s something where, in the 1990s, you probably would’ve ended up very lonely and depressed and totally unsupported. And with the internet, you’re not. You can find all kinds of people in exactly the same position as you and get that social support. And that’s an extreme example of what we find, which is you can form real relationships online. And that’s why I tend to resist this distinction between the real world and online. The real world absolutely exists online, and I’ve found lots of real friends who I’ve met offline, but also just keep up relationships with online, and it’s so important.

Rovner: So you and your husband, Ingo, don’t just take in rescue golden retrievers, you take in rescue golden retrievers that are often older and sicker and who have been the most neglected and the most mistreated. Was that something intentional or did it just happen?

Golbeck: It a little bit evolved that way. I got to say, I am always drawn to the seniors, and when I started fostering really wanted to get some seniors. That’s not most of the dogs that come into rescue, actually. It’s usually young dogs who people got and weren’t prepared for, and we fostered 20 of those dogs, too. But, eventually, we did get a pair of seniors. I always thought three dogs was too many, so we would have three with a foster. But I was like, I’ll never actually have three dogs. And then we got this bonded pair. Both were seniors, and so there were four dogs. And as soon as they showed up at my house, I was like, oh, they have always lived here. Now I have four dogs. What am I going to do? And it was great, of course. And about a year later, the rescue was like, “We have this 13-year-old and her people don’t want her. Will you take her?” And I asked my husband, I’m like, “What do you think about five dogs?” And he said, “What’s the difference between four and five? It’s fine.” So then we had five kind of old dogs, or old rescues, three of them were old rescues.

And I think, eventually, the rescue group started realizing that I’d just say yes to whatever they would give me. And so the dogs that they were having a hard time finding someone to take, I’d be like, “Yeah, sure, send them over.” It’s been so rewarding, though, to take these dogs who need a lot of love and attention and care and who haven’t been getting it and being able to give them the love and support and medical care that they need. It’s really rewarding. So I was interested, and then we stumbled our way into something that’s turned into a mission for both of us.

Rovner: So I know a lot has been written over the years about the science of how pets can improve human health and vice versa. I actually looked it up. I wrote my first pet therapy story in 1982. I was 5. No, seriously, it was my first job out of college. But you’ve done something with this book that I haven’t really seen before. You’ve merged a lot of the scientific study with some actual practical advice for pet owners. I assume that was very much on purpose.

Golbeck: Yeah. We didn’t want this to be a self-help book or a dog-training book. At the same time, there’s a lot of things that people want to know as they’re discovering the science of how they bond with their dogs. And so we try to work a little bit of tips in there, along with a lot of science and then stories from people who have really seen those benefits in their everyday relationship with their dogs.

Rovner: What’s been the response?

Golbeck: It’s interesting. I was like, I don’t know that all of this is super surprising. There are some surprising results in there. At the same time, what we’re basically saying is that dogs make us feel good and they love us back and we love them a whole lot. And I think anybody who has a dog knows that that’s true. And the response has been consistently people saying, “I was so excited to see my experience reflected in there.”

So we have, for example, a chapter about dogs in the community and how if you have a dog, you meet everybody in your neighborhood by walking your dog. And you don’t even know their names. You maybe know their dogs’ names. And people are like, “Oh yeah, that’s totally it.” But they also feel really validated because we have these feelings about our relationship with our dogs, and some people tell us that we’re crazy. Some people say that we’re making it up. And what people are finding in the book is that there’s actually a ton of really rigorous scientific research to support them having those feelings that they already have. So it’s this great way of being like, “Yes, I’m not crazy. My dog really does love me back. This really is as deep as I feel like it is.” So that’s been a great response that I wasn’t necessarily expecting that’s what it would be.

Rovner: Well, good. Well, Jen Golbeck, thank you for the book. Thank you for all you do. Thank you for what you do for golden retrievers and for the rest of us dog lovers out in the community.

Golbeck: My pleasure. Thanks for having me.

Rovner: OK, we are back and it’s time for our extra-credit segment. That’s when we each recommend a story we read this week we think you should read, too. As always, don’t worry if you miss it. We will post the links on the podcast page at kffhealthnews.org and in our show notes on your phone or other mobile device. Alice, why don’t you go first this week?

Ollstein: Yes. I chose a really upsetting and important investigation by my colleague Ariel Wittenberg. It hits at the intersection of health, labor, climate. It’s about mail carriers around the country who are dying from heat exposure. This is actually killing more male carriers than car crashes or dog bites or any of the things you think of being the hazards of that job. And not only is this happening amid soaring temperatures in the summers in a lot of places in the South, but the Postal Service is not following its own rules for training workers on how to notice the signs of dangerous heat exposure and take steps to protect themselves. And not only are they lying, according to these documents she obtained about having done these trainings, they are pressuring these workers to move faster, to not take breaks because of the competition from other private delivery services like Amazon. So really, really important piece.

Rovner: Yeah, and I think also important for everybody who works outside, with climate change. Riley, why don’t you go next?

Griffin: Yes, my colleague Robert Langreth also has a story in this week’s Bloomberg Businessweek issue, and it is titled “The Next Blockbuster Drug Might Be Made in Space.” It’s a fun one. It describes how companies, including Big Pharma names like Eli Lilly, are using microgravity to develop drugs and improve formulations of existing blockbusters. So it’s a fun read. You can find it in print or online.

Rovner: Not everything in tech is bad. Lauren.

Griffin: Not everything is bad.

Weber: I’m continuing the trend of shouting-out my colleagues this week. So a bunch of my colleagues had an investigation titled “Applesauce Lead Cases in Kids Surge Amid Questions on FDA Oversight.” And so we’ve all heard about these applesauce packets for toddlers and babies that were contaminated with lead, but the official FDA numbers say it’s only like 60-something cases, but my colleagues called around the state health departments and they believe it’s at least suspected in over 118 cases, potentially more, which leads to the question of how widespread is all of this.

It lends itself to the questions of: Is the FDA’s oversight enough, especially when it comes to baby food? This is not the first baby food issue we’ve obviously had in the last couple years. It really is just a horror story for everyone. I mean, you’re just trying to feed your kids stuff that they like and then they’re sucking on something that could damage their brain development and hurt them for years to come. Really heart-rending storyline, and my colleagues did a great job showing that this is much further-reaching than has been previously disclosed.

Rovner: So another continuing theme of this year, the FDA’s regulation of food as opposed to the FDA’s regulation of drugs and how that sometimes falls by the wayside. Well, my story is also from The Washington Post, by Kent Babb. It’s called “They Watched Their Husbands Win the Heisman — Then Lost Them to CTE.” And it’s a really wrenching story about how the very best players in college football have something else in common besides athletic talent: That, over the years, more and more have joined the not-so-exclusive club of ex-players with brain injuries and related behavioral … excuse me. Over the years, more and more have joined the not-so-exclusive club of ex-players with brain injuries and related behavioral issues.

It’s the serious dark side of a sport that is so beloved in the United States, including by me, and that deserves not just a hard look but action to prevent some of these horrendous aftereffects.

OK, that is our show. As always, if you enjoy the podcast, you can subscribe wherever you get your podcasts. We’d appreciate it if you left us a review; that helps other people find us, too. Special thanks, as always, to Francis Ying for his technical expertise and amazing patience. As always, you can email us your comments or questions. We’re at whatthehealth@kff.org, or you can still find me at X, @jrovner, or @julierovner at Bluesky and Threads. Alice.

Ollstein: I’m @AliceOllstein on X and @alicemiranda on Bluesky.

Rovner: Lauren.

Weber: I’m @LaurenWeberHP on X and clearly need to improve the rest of my social media profiles.

Rovner: Riley.

Griffin: You can find me on Threads and X @rileyraygriffin.

Rovner: We will be back in your feed next week. Until then, be healthy.

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1 year 7 months ago

Courts, Multimedia, Public Health, Abortion, KFF Health News' 'What The Health?', Opioids, Podcasts, U.S. Congress, Women's Health

PAHO/WHO | Pan American Health Organization

Urgent action needed to protect children and prevent the uptake of e-cigarettes

Urgent action needed to protect children and prevent the uptake of e-cigarettes

Cristina Mitchell

14 Dec 2023

Urgent action needed to protect children and prevent the uptake of e-cigarettes

Cristina Mitchell

14 Dec 2023

1 year 7 months ago

Health – Dominican Today

Barahona free of suspected cholera cases, dengue cases decreasing in the Dominican Republic

Gina Estrella Ramia, the Director of Risk Management and Disaster Assistance at the Ministry of Public Health, has confirmed that there are currently no suspected cases of cholera in Barahona.

This positive news comes as the Jaime Mota Regional University Hospital in Barahona considers closing its oral rehydration area, which had been set up for acute diarrheal diseases, due to the normalcy of the situation.

During a recent visit to Barahona, Dr. Estrella met with local authorities, the National Institute of Drinking Water and Sewage (Inapa), and the Ministry of Public Works to address water-related issues. She expressed optimism that the Barahona aqueduct, affected by a landslide in recent months, will be operational within a few weeks, ensuring a stable water supply for the area’s residents.

Regarding dengue fever, Eladio Pérez Antonio, the Vice Minister of Collective Health, reported a significant decrease in cases in recent weeks. Out of 99 municipalities, 50 reported no new cases of dengue. He explained that while dengue follows an endemic curve and cases are expected, the current numbers are within the expected range. The recent increase in cases has now subsided, returning to expected levels.

As of the current reporting, the Dominican Republic has registered a total of 23,036 dengue cases, with 983 of these occurring two weeks ago. The Ministry of Public Health continues to closely monitor the situation to ensure public health and safety.

1 year 7 months ago

Health

Healio News

Ibrutinib plus venetoclax represents ‘new standard therapy’ for advanced mantle cell lymphoma

Ibrutinib plus venetoclax demonstrated superior PFS and a higher complete response rate compared with ibrutinib plus placebo in patients with relapsed or refractory mantle cell lymphoma, according to study results.Findings from the phase 3 SYMPATICO study — presented at ASH Annual Meeting and Exhibition — additionally showed that the safety profile of ibrutinib (Imbruvica; Janssen, Pharmacyclic

s) plus venetoclax (Venclexta; AbbVie, Genentech) remained consistent with already known adverse events of either agent alone, according to the researchers.“The combination of these

1 year 7 months ago

PAHO/WHO | Pan American Health Organization

Despite notable progress, road safety remains urgent global issue

Despite notable progress, road safety remains urgent global issue

Cristina Mitchell

13 Dec 2023

Despite notable progress, road safety remains urgent global issue

Cristina Mitchell

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1 year 7 months ago

The Medical News

As foundation for ‘excited delirium’ diagnosis cracks, fallout spreads

When Angelo Quinto's family learned that officials blamed his 2020 death on "excited delirium," a term they had never heard before, they couldn't believe it. To them, it was obvious the science behind the diagnosis wasn't real.

When Angelo Quinto's family learned that officials blamed his 2020 death on "excited delirium," a term they had never heard before, they couldn't believe it. To them, it was obvious the science behind the diagnosis wasn't real.

1 year 7 months ago

KFF Health News

As Foundation for ‘Excited Delirium’ Diagnosis Cracks, Fallout Spreads

When Angelo Quinto’s family learned that officials blamed his 2020 death on “excited delirium,” a term they had never heard before, they couldn’t believe it. To them, it was obvious the science behind the diagnosis wasn’t real.

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Quinto, 30, had been pinned on the ground for at least 90 seconds by police in California and stopped breathing. He died three days later.

Now his relatives are asking a federal judge to exclude any testimony about “excited delirium” in their wrongful death case against the city of Antioch. Their case may be stronger than ever.

Their push comes at the end of a pivotal year for the long-standing, nationwide effort to discard the use of excited delirium in official proceedings. Over the past 40 years, the discredited, racially biased theory has been used to explain away police culpability for many in-custody deaths. But in October, the American College of Emergency Physicians disavowed a key paper that seemingly gave it scientific legitimacy, and the College of American Pathologists said it should no longer be cited as a cause of death.

That same month, California’s Democratic Gov. Gavin Newsom signed the nation’s first law to ban the term “excited delirium” as a diagnosis and cause of death on death certificates, autopsy reports, and police reports. Legislators in other states are expected to consider similar bills next year, and some law enforcement agencies and training organizations have dropped references to excited delirium from their policy manuals and pulled back from training police on the debunked theory.

Despite all that momentum, families, attorneys, policing experts, and doctors say much remains to be done to correct the mistakes of the past, to ensure justice in ongoing trials, and to prevent avoidable deaths in the future. But after years of fighting, they’re heartened to see any movement at all.

“This entire thing, it’s a nightmare,” said Bella Collins, Angelo’s sister. “But there are silver linings everywhere, and I feel so fortunate to be able to see change happening.”

Ultimately, the campaign against excited delirium seeks to transform the way police deal with people undergoing mental health crises.

“This is really about saving lives,” said Joanna Naples-Mitchell, an attorney who worked on an influential Physicians for Human Rights review of excited delirium.

Changing Law Enforcement Training

The use of the term “excited delirium syndrome” became pervasive after the American College of Emergency Physicians published a white paper on it in 2009. It proposed that individuals in a mental health crisis, often under the influence of drugs or alcohol, can exhibit superhuman strength as police try to control them, and then die suddenly from the condition, not the police response.

The ACEP white paper was significant in catalyzing police training and policy, said Marc Krupanski, director of criminal justice and policing at Arnold Ventures, one of the largest nonprofit funders of criminal justice policy. The theory contributed to deaths, he said, because it encouraged officers to apply greater force rather than call medical professionals when they saw people in aggressive states.

After George Floyd’s 2020 death, which officers blamed on excited delirium, the American Medical Association and the American Psychiatric Association formally rejected it as a medical condition. Then came disavowals from the National Association of Medical Examiners and the emergency physicians’ and pathologists’ groups this year.

The moves by medical societies to renounce the term have already had tangible, albeit limited, effects. In November, Lexipol, a training organization used by thousands of public safety agencies in the U.S., reiterated its earlier move away from excited delirium, citing the California law and ACEP’s retraction of the 2009 white paper.

Lexipol now guides officers to rely on what they can observe, and not to guess at a person’s mental status or medical condition, said Mike Ranalli, a lawyer and police trainer with the Texas-based group. “If somebody appears to be in distress, just get the EMS,” he said, referring to emergency medical services.

Patrick Caceres, a senior investigator at the Bay Area Rapid Transit’s Office of the Independent Police Auditor, successfully pushed to remove excited delirium from the BART Police Department’s policy manual after learning about Quinto’s death in 2020 and seeing the American Medical Association’s rejection of it the following year.

Caceres fears that rooting out the concept — not just the term — more broadly will take time in a country where law enforcement is spread across roughly 18,000 agencies governed by independent police chiefs or sheriffs.

“The kinds of training and the kinds of conversations that need to happen, we’re still a long way away from that,” said Caceres.

In Tacoma, Washington, where three police officers have been charged with the 2020 death of Manuel Ellis, The Seattle Times reported that local first responders testified as recently as October that they still “embrace” the concept.

But in Colorado, the state’s Peace Officer Standards and Training board ruled on Dec. 1 to drop excited delirium training for new law enforcement officers, KUSA-TV reported.

And two Colorado lawmakers, Democratic state Reps. Judy Amabile and Leslie Herod, have drafted a bill for the 2024 legislative session banning excited delirium from other police and EMS training and prohibiting coroners from citing it as a cause of death.

“This idea that it gives you superhuman strength causes the police to think they should respond in a way that is often completely inappropriate for what’s actually happening,” Amabile said. “It just seems obvious that we should stop doing that.”

She would like police to focus more on de-escalation tactics, and make sure 911 calls for people in mental health crisis are routed to behavioral health professionals who are part of crisis intervention teams.

Taking ‘Excited Delirium’ Out of the Equation

As the Quinto family seeks justice in the death of the 30-year-old Navy veteran, they are hopeful the new refutations of excited delirium will bolster their wrongful death lawsuit against the city of Antioch. On the other side, defense lawyers have argued that jurors should hear testimony about the theory.

On Oct. 26, the family cited both the new California law and the ACEP rebuke of the diagnosis when it asked a U.S. District Court judge in California to exclude witness testimony and evidence related to excited delirium, saying it “cannot be accepted as a scientifically valid diagnosis having anything to do with Quinto’s death.”

“A defense based on BS can succeed,” family attorney Ben Nisenbaum said. “It can succeed by giving jurors an excuse to give the cops a way out of this.”

Meanwhile, advocates are calling for a reexamination of autopsies of those who died in law enforcement custody, and families are fighting to change death certificates that blame excited delirium.

The Maryland attorney general’s office is conducting an audit of autopsies under the tenure of former chief medical examiner David Fowler, who has attributed various deaths to excited delirium. But that’s just one state reviewing a subset of its in-custody deaths.

The family of Alexander Rios, 28, reached a $4 million settlement with Richland County, Ohio, in 2021 after jail officers piled on Rios and shocked him until he turned blue and limp in September 2019. During a criminal trial against one of the officers that ended in a mistrial this November, the pathologist who helped conduct Rios’ autopsy testified that her supervisor pressured her to list “excited delirium” as the cause of death even though she didn’t agree. Still, excited delirium remains his official cause of death.

The county refused to update the record, so his relatives are suing to force a change to his official cause of death. A trial is set for May.

Changing the death certificate will be a form of justice, but it won’t undo the damage his death has caused, said Don Mould, Rios’ stepfather, who is now helping to raise one of Rios’ three children.

“Here is a kid that’s life is upside down,” he said. “No one should go to jail and walk in and not be able to walk out.”

In some cases, death certificates may be hard to refile. Quinto’s family has asked a state judge to throw out the coroner’s findings about his 2020 death. But the California law, which takes effect in January and bans excited delirium on death certificates, cannot be applied retroactively, said Contra Costa County Counsel Thomas Geiger in a court filing.

And, despite the 2023 disavowals by the main medical examiners’ and pathologists’ groups, excited delirium — or a similar explanation — could still show up on future autopsy reports outside California. No single group has authority over the thousands of individual medical examiners and coroners, some of whom work closely with law enforcement officials. The system for determining a cause of death is deeply disjointed and chronically underfunded.

“One of the unfortunate things, at least within forensic pathology, is that many things are very piecemeal,” said Anna Tart, a member of the Forensic Pathology Committee of the College of American Pathologists. She said that CAP plans to educate members through conferences and webinars but won’t discipline members who continue to use the term.

Justin Feldman, principal research scientist with the Center for Policing Equity, said that medical examiners need even more pressure and oversight to ensure that they don’t find other ways to attribute deaths caused by police restraint to something else.

Only a minority of deaths in police custody now cite excited delirium, he said. Instead, many deaths are being blamed on stimulants, even though fatal cocaine or methamphetamine overdoses are rare in the absence of opioids.

Yet advocates are hopeful that this year marks enough of a turning point that alternative terms will have less traction.

The California law and ACEP decision take “a huge piece of junk science out of the equation,” said Julia Sherwin, a California civil rights attorney who co-authored the Physicians for Human Rights report.

Sherwin is representing the family of Mario Gonzalez, who died in police custody in 2021, in a lawsuit against the city of Alameda, California. Excited delirium doesn’t appear on Gonzalez’s death certificate, but medical experts testifying for the officers who restrained him cited the theory in depositions. 

She said she plans to file a motion excluding the testimony about excited delirium in that upcoming case and similar motions in all the restraint-asphyxia cases she handles.

“And, in every case, lawyers around the country should be doing that,” Sherwin said.

This article was produced by KFF Health News, which publishes California Healthline, an editorially independent service of the California Health Care Foundation. 

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

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1 year 7 months ago

california, Mental Health, States, Colorado, Emergency Medicine, Legislation, Maryland, Ohio, Washington

Health News Today on Fox News

Blood test may predict the organs in the body that are aging faster than normal, says Stanford study

A simple blood test could detect which organs are aging at an accelerated pace for people who otherwise appear healthy, according to a recent study published on Dec. 7 in the journal Nature.

Researchers from Stanford University Medicine found that roughly one in every five "reasonably healthy" adults aged 50 or older has at least one organ that is aging at a "strongly accelerated rate," which causes a higher risk of disease and death.

The blood test could help guide therapeutic interventions before symptoms appear, according to senior author Tony Wyss-Coray, PhD, the senior author of the study and a professor of neurology at Stanford Medicine in California.

ALZHEIMER’S BLOOD TEST COULD HIT THE MARKET IN EARLY 2024, RESEARCHERS SAY

By looking at specialized proteins in a person’s blood, scientists could detect the biological age of an organ, even if the person appears healthy at the time, Wyss-Coray told Fox News Digital. 

That information could then predict the person’s risk for disease related to that organ.

Wyss-Coray compared it to an auto mechanic plugging a vehicle into a machine to get information about how the different car parts are functioning.

"This is basically what we do, but by looking at the concentration of these highly specialized proteins," he told Fox News Digital in an interview.

The research team — led by Stanford in collaboration with Washington University; the University of California, San Francisco; the Albert Einstein College of Medicine; and Montefiore Medical Center in New York — looked at blood samples from 5,678 people, focusing on proteins in the blood that are unique to specific organs. 

PITTSBURGH BOY, 10, NEEDS SECOND LIVER TRANSPLANT TO SAVE HIS LIFE: ‘ONLY POSSIBLE THROUGH LOVE’

"For example, because the brain is highly specialized, it uses very special proteins to maintain its function," Wyss-Coray said.

The team then created a model using an algorithm to detect the organs’ biological age.

"When we compared each of these organs’ biological age for each individual to their counterparts among a large group of people without obvious severe diseases, we found that 18.4% of those age 50 or older had at least one organ aging significantly more rapidly than the average," Wyss-Coray said in a news release from the university.

"These individuals were at a heightened risk for disease in that particular organ in the next 15 years."

Human organs age at different rates, lead authors Hamilton Oh and Jarod Rutledge, who are graduate students in Wyss-Coray’s lab, said in the Stanford news release.

Previous studies have examined ways to detect a person’s biological age through biomarkers, but the Stanford team took it a step further by determining scores for specific organs, including the heart, brain, kidney, liver, pancreas, lung, intestines, immune system and tissues. 

THESE ARE THE 10 LEADING CAUSES OF DEATH AMONG US ADULTS, THE CDC SAYS

The researchers used an algorithm that included organ-specific protein calculations and came up with an "age gap." That's the difference between an organ’s actual age and its estimated age based on the algorithm’s calculations, Wyss-Cross told Fox News Digital.

Age gaps were found for 10 of the 11 organs studied. An individual who had an accelerated-aging organ carried a 15% to 50% higher mortality risk over the next 15 years depending on which organ was affected, the study found.

Even for people who did not initially show any active disease or abnormal clinical biomarkers, an accelerated aging heart increased their risk of heart failure by 2.5 times, according to the study release.

Those considered to have "older" brains were 1.8 times as likely to show cognitive decline over five years, compared to those with "young" brains, the Stanford release noted.

Accelerated aging of the brain or vasculature (blood vessel) system also predicted risk for Alzheimer’s disease progression, according to the study.

There were also strong associations between an extreme-aging kidney score with diabetes and hypertension, as well as a link between an extreme-aging heart score and atrial fibrillation or heart attack, Wyss-Coray told Fox News Digital. 

A smaller number of individuals (1 in 60 people) had two organs that were aging at a faster pace. Their mortality risk was 6.5 times higher than a person without a significantly aged organ.

"If we can reproduce this finding in 50,000 or 100,000 individuals, it will mean that by monitoring the health of individual organs in apparently healthy people, we might be able to find organs that are undergoing accelerated aging in people’s bodies, and we might be able to treat people before they get sick," Wyss-Coray said in the release.

Another benefit of identifying accelerated organ aging is that it can help with drug repurposing, he noted.

"Let’s say you take a drug for heart disease and we saw that as a result, your lung gets younger," Wyss-Coray told Fox News Digital in the interview. "It could be another effect of that drug. Then maybe we can use that same drug to treat a lung disease."

OVARIAN CANCER COULD BE DETECTED EARLY WITH A NEW BLOOD TEST, STUDY FINDS

Identifying these proteins can also lead to new drug targets, Wyss-Coray added.

If proteins are shown to decline in people who get a disease, scientists could make more of them, for example — or other proteins could be inhibited if they are detrimental.

Dr. Anuradha Lala, M.D., an advanced heart failure and transplant cardiologist at Mount Sinai Fuster Heart Hospital in New York City, was not affiliated with the study, but told Fox News Digital that the findings may help to increase organ donations. 

In heart transplant medicine, doctors typically select relatively younger, healthier donors to maximize the longevity of the transplanted organ, Lala noted.

"Yet the authors showed … that aging in one organ did not necessarily mean other organs age at the same rate," she told Fox News Digital. 

"Given the large number of patients awaiting life-saving transplantation of specific organs, being able to decipher which organs may indeed have better chances of doing well could theoretically increase the number of donor [hearts] available," Lala said. 

More research is needed into the implications of race, ethnicity and gender, as well as costs and access, she added.

Sean Clouston, PhD, a professor in the Department of Family, Population and Preventive Medicine in the Renaissance School of Medicine at Stony Brook University in New York, was not involved in the study but commented on the research.

"This is a remarkably complicated but intuitive study that used exceptional measurements to examine aging separately across different organ systems," Clouston, who is also the director of public health research, said via email to Fox News Digital.

The study findings could help practitioners identify and treat many types of conditions, he added.

"This could mean that you could go to your doctor to do one blood test to monitor a huge array of conditions … and maybe they could act earlier to intervene for problems that are still only emerging."

Existing treatments, including those for Alzheimer’s disease, could also become much more effective, Clouston noted.

Two doctors from Northwell Health on Long Island, New York — Dr. Christine L. Sardo Molmenti, PhD, an associate professor and cancer epidemiologist, and Dr. Ernesto P. Molmenti, MD, Ph.D., surgical director of kidney transplantation — were not involved in the study but weighed in on the findings.

The findings "bring us closer to the concept of individualized and personalized medicine," they said in a joint statement to Fox News Digital.

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"They are able to identify, in a minimally invasive way, which organs will require immediate, intermediate and/or long-term therapeutic interventions," the doctors said.

"Once an organ has been identified as actively aging, it may allow for providing optimal medical care and improving prognosis and survival," they continued. 

"With our ultimate goal of intervening prior to the progression of disease, this approach also focuses on prevention as a promising strategy for reducing morbidity and mortality of several chronic diseases that are leading causes of death in this country."

For more Health articles, visit www.foxnews.com/health

1 year 7 months ago

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Linagliptin and Dapagliflozin: Therapeutic Applicability in T2DM with High CV Risk

Type 2 Diabetes Mellitus and Cardiovascular Disease

Type 2 diabetes mellitus (T2DM) prevalence has been increasing globally, particularly in India (1) T2DM in general increases the risk of CVD outcomes by a twofold and is independent of other risk factors. (1) The risk of coronary artery disease (CAD) in Indian T2DM patients is two to four times higher, and CAD occurs one to two decades earlier than in the West. (3) Impaired glucose metabolism, inflammation, and abnormal cell signaling all contribute to premature atherosclerosis, myocardial remodeling, and left ventricular fibrosis, which contribute to cardiovascular damage. (2)

Managing Cardiovascular Disease in Diabetes: Going Beyond HbA1c

The focus of CVD management in diabetes should extend beyond glycemic control and on antidiabetic drugs that alleviate the risk factors and improve CV outcomes. It is critical to identify pharmacological strategies that target cardiovascular inflammation, fibrosis; induce weight and blood pressure reduction; and provide renal and cardiovascular protection in managing CVD in T2DM.

Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a unique class of antidiabetic drugs. The primary advantage of SGLT2i is that they act independently of insulin, inhibiting proximal tubular glucose reabsorption and lowering plasma glucose levels and glucosuria. They also provide organ protection, including cardio-renal protection, lowering the risk of heart failure and cardiovascular mortality due to their direct and indirect pleiotropic effects. (2)

Dipeptidyl peptidase 4 (DPP4) inhibitors also reduce myocardial inflammation by inhibiting cytokine release, monocyte activation, and chemotaxis. Also, gliptins improve systolic and diastolic left ventricular dysfunction in CV diseases and support overall cardiovascular protection. (4)

Optimising Guideline Directed Medical Therapy in T2DM & High-Risk CVD

  • The RSSDI (Research Society for the Study of Diabetes in India) Clinical Practice Recommendations for the Management of Type 2 Diabetes: The RSSDI 2022 guidelines suggested the use of dual therapy to achieve glucose targets or to extend the time to treatment failure and also recommended using antidiabetic agents, including SGLT2 and DPP-4 inhibitors. The guideline further recommended SGLT2i for patients with established or high risk for ASCVD, heart failure, and in need of weight reduction. In elderly patients with an increased risk of hypoglycemia, the guideline suggested the use of DPP-4 inhibitors. (5)
  • American Association of Clinical Endocrinology (AACE) Consensus Statement for Management of Type 2 Diabetes Mellitus: The 2023 update for T2DM Management recommends using SGLT2 inhibitors to improve cardiorenal outcomes. AACE guidelines recommend SGLT2 inhibitors as first-line treatment for cardiorenal risk reduction regardless of background metformin use or HbA1c level within the complications-centric algorithm. (6)
  • ESC Guidelines for the Management of Cardiovascular Disease in Patients with Diabetes: The 2023 ESC Guideline for “Management of Cardiovascular Disease in Diabetes” recommend SGLT2i (Class I) to reduce CV risk independent of glucose control in T2DM with ASCVD. (7).
  • International Guidelines Expanding the Applicability of SGLT2-inhibitors: The ESC Guideline for ”Management of Cardiovascular Disease in Diabetes 2023 (7), the American Diabetes Association (ADA) “Standards of Care in Diabetes” 2023 (8), and the Kidney Disease Improving Global Outcomes (KDIGO) 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease (9) recommended the use of SGLT2i for patients with T2DM and CKD who have eGFR ≥20 mL/min/1.73 m2.

Scientific Rationale for Considering Linagliptin & Dapagliflozin among T2DM Patients with High CV Risk

Linagliptin: The Gliptin Applicable in Wide Group of Type 2 Diabetes Patients Improving Macrovascular & Microvascular Complications: Linagliptin is a DPP-4 inhibitor with potent and durable DPP-4 inhibition. It is known to increase GLP-1(glucagon-like peptide-1) and GIP (gastric inhibitory polypeptide) levels, which may provide beneficial cardioprotection (10)

  • Linagliptin treatment benefits CV dysfunction associated with T2DM. It decreases cardiac hypertrophy and fibrosis and improves cardiac function (11)
  • Linagliptin treatment also provides renal protection by lowering albuminuria, and tubulo-interstitial fibrosis and preventing the progression of renal tissue injury.
  • It also decreases inflammation and pericytes and provides retinal capillary vaso-regression, thereby providing protection in retinopathy. (11)
  • Linagliptin also benefits neuropathy by suppressing arterial stiffening and vascular inflammation and improving vascular relaxation. (11)

Dapagliflozin: Durable Evidence with Robust Glycemic & CV-CKD Benefits

Dapagliflozin is a widely utilized SGLT2i in clinical settings. The mechanism of dapagliflozin in cardiovascular protection may involve improving ventricular loading conditions, improvement of cardiac metabolism and bioenergetics, Na+/H+ exchange, sugar and lipid metabolism & circulatory load. (12)

  • It improves cardiorenal outcomes through various pathways, including by reducing blood pressure, arterial stiffness, and endothelial dysfunction. (12)
  • Dapagliflozin treatment lowers the risk of hospitalization for heart failure, CV death, and all-cause mortality. (13)
  • It improves glomerular hemodynamics, resulting in long-term kidney function preservation. It provides renoprotective benefits regardless of diabetes status, age, cause of CKD, baseline albuminuria, and eGFR. (13)

Beneficial Impact of Linagliptin and Dapagliflozin on CV Outcomes- Clinical Evidence

Linagliptin Leads to CV Risk Reduction in Asian Type 2 Diabetes Patients: A real-world observational study evaluated the effect of linagliptin on CV risk reduction in Asian T2DM patients. The study enrolled 73 patients on Linagliptin and noted that the 12-month treatment with Linagliptin significantly reduced CV risk by 6.36% (P=0.17). It also reduces the atherosclerotic cardiovascular disease risk in patients with high ASCVD risk and the elderly population. These findings showed a promising effect of Linagliptin in cardiovascular risk reduction in Asian T2DM patients with higher baseline cardiovascular risk and older age. (14)

Linagliptin Improves Microalbuminuria in Diabetic Nephropathy: A double-blind, randomized, placebo-controlled trial analyzed the effect of linagliptin on microalbuminuria in patients with diabetic nephropathy (DN). The trial enrolled 92 patients with DN, divided into the intervention and control groups, who received linagliptin 5 mg and placebo for 24 weeks, respectively. Linagliptin significantly improved microalbuminuria (urine albumin creatinine ratio of < 30 mg/g) by 68.3% (p<0.001). This suggests that linagliptin therapy improves microalbuminuria in diabetic nephropathy patients. (15)

CARMELINA and CAROLINA: Linagliptin Reassures for CV Safety in Asian T2DM Patients:

The CARMELINA trial's subgroup analysis explored Linagliptin's CV safety in Asian T2DM (N=6979, 8.0% Asian). Linagliptin treatment reduced the risk of hospitalization for heart failure (HR 0.47; 95% CI 0.24–0.95; P=0.0368), the composite of hospitalization for heart failure or all-cause mortality (HR 0.55; 95% CI 0.32–0.95; P=0.2191), and all-cause hospitalization (HR 0.74; 95% CI 0.57–0.96; P=0.2182). This suggests the CV safety of linagliptin in Asian T2DM patients. (16)

Another subgroup analysis of the CAROLINA trial assessed the CV outcomes of linagliptin among Asian T2DM patients. Linagliptin reduced 3P-MACE (first occurrence of CV death, non-fatal MI, or non-fatal stroke events, HR 0.85), 4P-MACE (CV death, non-fatal myocardial infarction, non-fatal stroke, or hospitalization for unstable angina HR 0.86; 95% CI 0.59–1.26), all-cause mortality (HR 0.74; 95% CI 0.46–1.20) over a follow-up of 6.2 years. These findings suggest the CV safety of Linagliptin in Asian T2DM patients. (17)

Dapagliflozin for CV risk reduction-Insights from DECLARE TIMI 58 Trial: The DECLARE TIMI 58 trial assessed the effect of Dapagliflozin; enrolling 17160 patients with T2DM; 6974 had known ASCVD, of whom 3584 had a history of MI, with a median duration of 5.4 years from their last event. The trial randomized the participants to receive dapagliflozin (10mg once daily) or a placebo. Dapagliflozin significantly reduced MACE by 16% (hazard ratio [HR], 0.84; 95% CI, 0.72–0.99; P=0.039) in those with a history of prior MI. The efficacy result based on ejection fraction showed that in T2DM with Heart Failure with reduced Ejection Fraction (HFrEF), dapagliflozin treatment reduced CV death by 45%, hospitalization for HF by 36%, and all-cause mortality by 41%. Among HF without reduced EF, the treatment reduced CV death by 12% and hospitalization for HF by 24%. These findings suggest the CV benefit & safety of dapagliflozin in T2DM patients. (18)

Dapagliflozin Improves Cardio-Renal Outcomes in DAPA CKD Trial: The Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) trial, designed in a randomized, double-blind, placebo-controlled, multicenter design, assessed the long-term efficacy and safety of the SGLT2 inhibitor dapagliflozin in patients with chronic kidney disease, with or without type 2 diabetes. The trial enrolled 4304 subjects with an eGFR of 25-75 ml/minute/1.73 m2. Treatment with dapagliflozin has a lower hazard ratio for the composite of a sustained decline in the eGFR of at least 50%, end-stage kidney disease, or death from renal causes was by 35% (95% CI, 0.45 to 0.68; P<0.001), reduced the chance of composite of death from cardiovascular causes or hospitalization for heart failure by 41% (95% CI, 0.55 to 0.92; P=0.009). The study's findings highlight Dapagliflozin's renal safety and benefit in T2DM patients with CKD. (19)

Robust Clinical Benefits of Linagliptin & Dapagliflozin in High CV Risk Patients

  • Linagliptin therapy provides beneficial cardiorenal protection, and its use is guideline-directed owing to its CV safety profile. (7,11)
  • Linagliptin treatment improves microalbuminuria (urine albumin creatinine ratio of < 30 mg/g) by 68.3% among patients with diabetic nephropathy(DN). (15)
  • Dapagliflozin is a glucose-lowering agent with CV benefits and provides cardio-protection and renal protection in T2DM patients. (12,13)
  • Dapagliflozin treatment reduces seated SBP by 10.4 mmHg (21), 24-hour ambulatory BP by 9.6 mmHg (21), weight by 4.27 kgs (22), BMI by 1.53 kg/m2 (22), and left ventricular mass by 2.82g (22).
  • Dapagliflozin reduces CV death by 45%, hospitalization for HF by 36%, and all-cause mortality by 41%. (18)
  • Dapagliflozin reduces albuminuria by 33% and reduces death from renal causes in T2DM patients. (19)

Clinical Takeaways:

  • Managing CVD in patients with T2DM is a rapidly evolving scientific field, and using antidiabetic agents with proven CV safety is important in this patient population.
  • Linagliptin provides cardioprotection benefits, and dapagliflozin improves ventricular loading conditions, cardiac metabolism, and bioenergetics.
  • Linagliptin treatment improves the progression of CKD and reduces microalbuminuria in diabetic nephropathy.
  • Dapagliflozin improves cardiorenal outcomes through various pathways, including reducing blood pressure, arterial stiffness, and endothelial dysfunction.
  • Dapagliflozin treatment led to a reduction in heart failure hospitalization, CV death, and all-cause mortality in patients with diabetes and high CV risk. Treatment with dapagliflozin prevents CKD progression, ESKD, and death from renal causes.

Linagliptin and dapagliflozin seem effective in achieving glycemic control, alleviating CV risk factors and improving CV-CKD outcomes; potentially allowing these agents to be an ‘evergreen duo’ in the management of the Type 2 Diabetes continuum.

References:

1. Unnikrishnan AG, Sahay RK, Phadke U, Sharma SK, Shah P, Shukla R, Viswanathan V, Wangnoo SK, Singhal S, John M, Kumar A, Dharmalingam M, Jain S, Shaikh S, Verberk WJ. Cardiovascular risk in newly diagnosed type 2 diabetes patients in India. PLoS One. 2022 Mar 31;17(3):e0263619. doi: 10.1371/journal.pone.0263619.

2. Hodrea J, Saeed A, Molnar A, Fintha A, Barczi A, Wagner LJ, Szabo AJ, Fekete A, Balogh DB. SGLT2 inhibitor dapagliflozin prevents atherosclerotic and cardiac complications in experimental type 1 diabetes. PLoS One. 2022 Feb 17;17(2):e0263285. doi: 10.1371/journal.pone.0263285.

3. Mohan V, Venkatraman JV, Pradeepa R. Epidemiology of cardiovascular disease in type 2 diabetes: the Indian scenario. J Diabetes Sci Technol. 2010;4(1):158-170. Published 2010 Jan 1. doi:10.1177/193229681000400121

4. Zakaria EM, Tawfeek WM, Hassanin MH, Hassaballah MY. Cardiovascular protection by DPP-4 inhibitors in preclinical studies: an updated review of molecular mechanisms. Naunyn Schmiedebergs Arch Pharmacol. 2022;395(11):1357-1372. doi:10.1007/s00210-022-02279-3

5. Kumar V, Agarwal S, Saboo B, Makkar B. RSSDI Guidelines for the management of hypertension in patients with diabetes mellitus [published online ahead of print, 2022 Dec 15]. Int J Diabetes Dev Ctries. 2022;42(Suppl 1):1-30. doi:10.1007/s13410-022-01143-7

6. Samson SL, Vellanki P, Blonde L, Christofides EA, Galindo RJ, Hirsch IB, Isaacs SD, Izuora KE, Low Wang CC, Twining CL, Umpierrez GE, Valencia WM. American Association of Clinical Endocrinology Consensus Statement: Comprehensive Type 2 Diabetes Management Algorithm - 2023 Update. Endocr Pract. 2023 May;29(5):305-340. doi: 10.1016/j.eprac.2023.02.001. Erratum in: Endocr Pract. 2023 Sep;29(9):746.

7. Marx N, Federici M, Schütt K, Müller-Wieland D, Ajjan RA, Antunes MJ, Christodorescu RM, Crawford C, Di Angelantonio E, Eliasson B, Espinola-Klein C, Fauchier L, Halle M, Herrington WG, Kautzky-Willer A, Lambrinou E, Lesiak M, Lettino M, McGuire DK, Mullens W, Rocca B, Sattar N; ESC Scientific Document Group. 2023 ESC Guidelines for the management of cardiovascular disease in patients with diabetes. Eur Heart J. 2023 Oct 14;44(39):4043-4140. doi: 10.1093/eurheartj/ehad192.

8. ElSayed NA, Aleppo G, Aroda VR, et al. 11. Chronic Kidney Disease and Risk Management: Standards of Care in Diabetes-2023. Diabetes Care. 2023;46(Suppl 1):S191-S202. doi:10.2337/dc23-S011

9. Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group. KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease. Kidney Int. 2022 Nov;102(5S):S1-S127. doi: 10.1016/j.kint.2022.06.008.

10. Johansen, O.E., Neubacher, D., von Eynatten, M. et al. Cardiovascular safety with linagliptin in patients with type 2 diabetes mellitus: a pre-specified, prospective, and adjudicated meta-analysis of a phase 3 programme. Cardiovasc Diabetol 11, 3 (2012). https://doi.org/10.1186/1475-2840-11-3

11. Aroor AR, Manrique-Acevedo C, DeMarco VG. The role of dipeptidylpeptidase-4 inhibitors in management of cardiovascular disease in diabetes; focus on linagliptin. Cardiovasc Diabetol. 2018 Apr 18;17(1):59. doi: 10.1186/s12933-018-0704-1.

12. Zhai M, Du X, Liu C, Xu H. The Effects of Dapagliflozin in Patients With Heart Failure Complicated With Type 2 Diabetes: A Meta-Analysis of Placebo-Controlled Randomized Trials. Front Clin Diabetes Healthc. 2021 Jun 30;2:703937. doi: 10.3389/fcdhc.2021.703937.

13. Bell, DSH, McGill, JB, Jerkins, T. Management of the ‘wicked’ combination of heart failure and chronic kidney disease in the patient with diabetes. Diabetes Obes Metab. 2023; 25(10): 2795-2804. doi:10.1111/dom.15181

14. Poonchuay N, Wattana K, Uitrakul S. Efficacy of linagliptin on cardiovascular risk and cardiometabolic parameters in Thai patients with type 2 diabetes mellitus: A real-world observational study. Diabetes Metab Syndr. 2022 May;16(5):102498. doi: 10.1016/j.dsx.2022.102498. Epub 2022 May 13.

15. Karimifar, M., Afsar, J., Amini, M. et al. The effect of linagliptin on microalbuminuria in patients with diabetic nephropathy: a randomized, double-blinded clinical trial. Sci Rep 13, 3479 (2023). https://doi.org/10.1038/s41598-023-30643-7

16. Inagaki N, Yang W, Watada H, et al. Linagliptin and cardiorenal outcomes in Asians with type 2 diabetes mellitus and established cardiovascular and/or kidney disease: subgroup analysis of the randomized CARMELINA® trial. Diabetol Int. 2019;11(2):129-141. Published 2019 Oct 22. doi:10.1007/s13340-019-00412-x

17. Kadowaki T, Wang G, Rosenstock J, et al. Effect of linagliptin, a dipeptidyl peptidase-4 inhibitor, compared with the sulfonylurea glimepiride on cardiovascular outcomes in Asians with type 2 diabetes: subgroup analysis of the randomized CAROLINA® trial. Diabetol Int. 2020;12(1):87-100. Published 2020 Jun 27. doi:10.1007/s13340-020-00447-5

18. Verma S, McMurray JJV. The Serendipitous Story of SGLT2 Inhibitors in Heart Failure. Circulation. 2019 May 28;139(22):2537-2541. doi: 10.1161/CIRCULATIONAHA.119.040514. Epub 2019 Mar 18.

19. Heerspink HJL, Stefánsson BV, Correa-Rotter R, Chertow GM, Greene T, Hou FF, Mann JFE, McMurray JJV, Lindberg M, Rossing P, Sjöström CD, Toto RD, Langkilde AM, Wheeler DC; DAPA-CKD Trial Committees and Investigators. Dapagliflozin in Patients with Chronic Kidney Disease. N Engl J Med. 2020 Oct 8;383(15):1436-1446. doi: 10.1056/NEJMoa2024816. Epub 2020 Sep 24.

20. McGill JB. Linagliptin for type 2 diabetes mellitus: a review of the pivotal clinical trials. Ther Adv Endocrinol Metab. 2012;3(4):113-124. doi:10.1177/2042018812449406

21. Weber MA, Mansfield TA, Alessi F, Iqbal N, Parikh S, Ptaszynska A. Effects of dapagliflozin on blood pressure in hypertensive diabetic patients on renin-angiotensin system blockade. Blood Press. 2016;25(2):93-103. doi: 10.3109/08037051.2015.1116258. Epub 2015 Dec 1. Erratum in: Blood Press. 2016 Aug;25(4):x.

22. Brown AJM, Gandy S, McCrimmon R, Houston JG, Struthers AD, Lang CC. A randomized controlled trial of dapagliflozin on left ventricular hypertrophy in people with type two diabetes: the DAPA-LVH trial. Eur Heart J. 2020 Sep 21;41(36):3421-3432. doi: 10.1093/eurheartj/ehaa419.

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