“Surprisingly fine,” said Conway-Anderson, a 36-year-old agroforestry professor at the University of Missouri. There was an 11-millimeter precancerous polyp that the doctors had discovered, but they’d snipped it out of her colon and recommended surveillance every three years. “Obviously, it’s big news to hear, but grateful this seems to be manageable. I’ll do it,” she said. “Then the bill came.”

She was being charged nearly $12,000 for the procedure after insurance. Conway-Anderson’s head spun. She couldn’t understand how it could cost so much, especially when she thought the colonoscopy was preventative for cancer and thus covered. “I was floored,” she said. “I was like I can’t pay this. I don’t know what you want me to do.”

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Better care for cancer patients may be on the horizon.

A new prescription medicine for treating cervical cancer has been showing positive results in clinical trials.

In phase 3 global trials, TIVDAK (tisotumab vedotin) was linked to a 30% overall reduction in the risk of death compared to chemotherapy.

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TIVDAK also demonstrated a 33% decrease in the risk of worsening disease or death.

In addition, the intravenous drug showed an improved objective response rate of 17.8% compared to chemotherapy at 5.2%.

The trial also measured the disease control rate, which is the percentage of patients who experience complete response, partial response or stable disease.

TIVDAK displayed a 75.9% disease control rate, while chemo showed a 58.2% rate.

In an interview with Fox News Digital, Dr. Brian Slomovitz, director of gynecologic oncology at Mount Sinai Medical Center in Miami Beach, Florida, emphasized the importance of these findings.

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"To have an overall survival advantage in this disease is extremely, extremely rare," he said.

"It changes the second-line standard of care for this disease. Now, all patients who recur after first-line therapy should be considered for this therapy," Slomovitz added. "So it's a game-changer."

Slomovitz, who has been directly involved in the trials, explained that the new class of drugs attacks a certain protein on the cell, which allows chemotherapy to be delivered to the cell "in a precise fashion."

He said, "So, it doesn't give a lot of the peripheral side effects that we see with traditional chemotherapy."

Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, is not involved in the drug's development or testing, but he believes the drug shows promise as an effective treatment.

"Cervical cancer can be a very aggressive disease, difficult to diagnose early, with a poor prognosis when it is metastatic," he told Fox News Digital.

"It is generally treated with multiple drugs, including chemo and radiation, which can shrink the tumor but very often does not cure it," he added. "The new targeted therapy TIVDAK, which includes a monoclonal antibody against the tissue factor associated with the tumor, is an "effective additional and useful therapy with a high response rate."

TIVDAK has shown ocular side effects such as conjunctivitis (pink eye), peripheral neuropathy (weakness, numbness, and pain from nerve damage) and some bleeding, but Dr. Kathleen Moore, associate director of clinical research at Stephenson Cancer Center in Oklahoma City, said she felt that is manageable.

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Moore has been administering TIVDAK to her patients since the FDA’s accelerated approval in 2021. 

She reported that they haven’t had a difficult time managing and offsetting side effects. Patients usually find relief by using prescription eye drops prior to beginning treatment and cold compresses to mitigate potential toxicity, Moore said.

"There's not been a single issue with a patient not being able to use the eyedrops and be compliant with all the mitigation strategies in order to obtain the benefit from this medication," she said.

Only 5% of patients have had to discontinue treatment due to side effects, Slomovitz reported.

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Chemotherapy, comparatively, shows a "much higher risk" of side effects, including anemia, nausea, hair loss and neutropenia, according to Slomovitz.

"We’re hoping that a treatment like [TIVDAK] is something that the patients prefer as opposed to the chemotherapy option," he said.

"As clinicians, we feel that the side effects are very manageable — and given the overall increase in efficacy, it's something that our patients are willing to have."

Moore mentioned that Oklahoma has "quite a bit of experience" with TIVDAK, since there is a large population of cervical cancer patients who present with "very advanced disease or metastatic disease at diagnosis" and require the treatment.

The doctor, who is also a drug developer, said her patients have done "very well" with the drug and appreciate its effectiveness and accessibility through insurance.

CERVICAL CANCER: WHAT ARE THE SIGNS AND SYMPTOMS?

"That's unheard of," she said. "In the past, we just did not have active medications and our patients really were left with ineffective therapies, and they just died."

Patients are recognizing that TIVDAK has worked to shrink their tumors, Moore said, which then leads to less pain and reduced dosage of medication.

"They’re feeling better because their disease is shrinking," she said.

TIVDAK has been used in practice since phase 2 trials led to accelerated approval by the FDA in the U.S.

The drug, however, could not earn full FDA approval until phase 3 was complete, Slomovitz noted.

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"We're hoping that the FDA approves this for a confirmatory trial in the setting, which would obviously have a great impact on the care of our patients," he said.

Slomovitz said he’s optimistic the FDA will give full approval for the drug in the "near future."

Both doctors shared their hopes for FDA drug clearance globally.

"We're starting to see, finally, improvements in therapies for patients who have advanced metastatic cervical cancer, all improving overall survival," Moore said. "So it is looking brighter."

Cervical cancer is the fourth most deadly cancer in female patients, according to Slomovitz.

Moore pointed out that the best way to avoid cervical cancer is to prevent it through annual screenings and vaccinations.

"This is an entirely preventable disease," she said. 

"The correct way to cure is to prevent, so that’s what we should be doing, too."

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The most obvious partner would be Mass General Brigham, the large, not-for-profit system that operates the Boston hospital where Dana-Farber’s doctors currently treat cancer patients. But after seven years of negotiations with MGB’s top brass — including about 30 meetings in the past 10 months alone — she said it became clear that they weren’t interested.

“It would have been easier if MGB would have said, ‘Yes, we can do that with you,’” Glimcher told The Boston Globe’s editorial board on Tuesday. “That would have been the easiest path. But they refused over and over and over again.”

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Prostate cancer is a disease found in men that develops in the prostate gland. 

One in eight men will be diagnosed with prostate cancer in their lifetime, according to the American Cancer Society (ACS), with older men more likely to develop the disease. 

Prostate cancer is second only to skin cancer as the most common cancer diagnosed in men, according to the source. 

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Symptoms of prostate cancer are typically very minimal, or not experienced at all. 

Below is all you need to know about prostate cancer.

Any type of cancer starts when cells grow out of control in certain parts of the body. 

Nearly every part of the body can be affected by cancerous cells, and they can then spread to other areas. 

RISKS, SYMPTOMS AND TREATMENTS FOR LUNG CANCER, THE DEADLIEST CANCER IN THE WORLD

Prostate cancer is a type of cancer found in men that begins in the prostate gland and can then grow beyond that in more severe cases. 

"The most common symptom is no symptom at all," Dr. Christopher Anderson, a urologist with New York-Presbyterian/Columbia University Irving Medical Center, previously told Fox News Digital in 2017.

Some men may experience symptoms such as pain in their bones and weight loss when the cancer has already spread, Anderson said.

Dr. Philip Kantoff, a medical oncologist and chair of the department of medicine at Memorial Sloan Kettering Cancer Center, reiterated that the disease does not typically cause symptoms. 

Symptoms could instead be due to an enlarged or inflamed prostate, neither of which are cancerous.

Dr. Ketan Badani, vice chairman of urology at Mount Sinai Health System, said that "some patients may have vague urinary complaints," like having to urinate more frequently, and that there are no symptoms until the disease is advanced. 

The majority of men who have urinary issues do not have prostate cancer, he noted.

Men ages 60 to 74 are considered more at risk, according to the Surveillance, Epidemiology and End Results (SEER) program. 

Family history, "especially a first-degree relative like a father or brother" who has been diagnosed, is another concern, Badani added.

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African, Afro-Caribbean, South Asian and Hispanic men are more at risk for "more aggressive" forms of prostate cancer, he said.

For men of African descent, there is an increased risk of both prostate cancer diagnosis and dying from prostate cancer, Anderson said.

There are several lifestyle changes men can implement into their lives to potentially reduce their risk of prostate cancer. This includes maintaining a healthy weight, staying active and having a healthy diet, according to the ACS, such as one including very little red and processed meat and processed foods, but filled with lots of fruits, vegetables and whole grains. 

Most commonly, prostate cancer is adenocarcinomas, meaning it develops in the gland cells, according to ACS.

There are other types of prostate cancer, according to the source, but these are rare. 

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Other types are small cell carcinoma, neuroendocrine tumors, transitional cell carcinomas and sarcomas.

In general, prostate cancer grows very slowly. 

Many people who have it die from other causes without ever knowing that they had the cancer, according to the ACS.

Prostate cancer is curable, so long as it's diagnosed early enough, according to Mayo Clinic.

Treatment options will depend on the stage of the cancer and the overall health of the individual. For early prostate cancer, immediate treatment may not be needed, per the source. 

More severe cases of cancer are usually treated through radiation or surgery.

"A discussion with your physician is warranted before symptoms occur," Kantoff advised, adding that men should decide with their doctors if a prostate-specific antigen (PSA) test, which looks at the level of PSA in blood, is right for them.

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Badani recommended that men receive both annual digital rectal exams and PSA tests. Multiple PSA tests over time are a better indicator of potential concerns as opposed to a single test result, he explained.

If you are concerned you might have prostate cancer, speak to an internal medicine doctor or a urologist, Anderson recommended. He stressed that all patients with blood in their urine should see a urologist.

PSA screening has been a controversial topic in the past. In 2012, the U.S. Preventative Services Task Force recommended against PSA screening when it said "there is moderate certainty that the benefits of PSA-based screening for prostate cancer do not outweigh the harms." 

In 2018, the task force said in its final recommendation that men ages 55 to 69 should discuss potential benefits and negatives of a PSA screening with their physician before undergoing the test. 

While a PSA screening has the potential to reduce the risk of death, negatives listed by the task force include "false-positive results that require additional testing and possible prostate biopsy; overdiagnosis and overtreatment; and treatment complications, such as incontinence and erectile dysfunction."

They do not recommend PSA screening in men ages 70 and above.

"Proper use of PSA is what I recommend from an early detection standpoint," Kantoff said.

Symptoms should not be the motivating factor for screening, he said, saying it should instead be a decision in one’s 40s about whether PSA testing should be done. He recommended that those with a family history or people of African American descent think about early detection.

An analysis of previous clinical trials published in 2017 said screening lessened the risk of dying from prostate cancer by 25 to 32% compared to men who did not get screened, a summary for patients explains online. 

The Associated Press contributed reporting, as did Andy Sahadeo and Zoe Szathmary. 

The lawsuit resurfaces longstanding concerns associated with hospitals buying up physician groups and then forcing those physicians to refer patients to the hospitals’ own facilities, even if that’s not in a patient’s best interest. Hospitals have increasingly acquired physician groups over the past 15 years, and in the process have entrenched monopoly positions for certain types of care by preventing patients from “leaking” to competitors.

Obtaining more market share and negotiating power isn’t the only incentive for hospitals to scoop up physicians. Oncology, in particular, is a lucrative specialty for hospitals to own. Revenue is immediately boosted because hospitals are able to charge more for the cancer doctors’ services in a hospital-owned clinic, even though those same services would be significantly cheaper in an independent clinic. Hospitals that participate in a federal drug discount program, known as 340B, also are able to buy expensive chemotherapy drugs for cheap while still billing insurers full freight.

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Shementé Jones knew something wasn’t right. Her back hurt. She felt pain during sex.

She said she kept telling her doctor something was wrong.

Her doctor told her, “Just wash your underwear in Dreft,” Jones said, referring to a brand of detergent.

Within months of that 2016 appointment, Jones, who lives in a suburb of Jackson, Mississippi, was diagnosed with stage 3 cervical cancer. She underwent a hysterectomy then weeks of radiation therapy.

“I ended up fine,” said Jones, now 43. “But what about all the other women?”

The question is especially pertinent in Jones’ home state, which had the nation’s second-highest age-adjusted cervical cancer mortality rate, 3.4 deaths per 100,000 women and girls annually from 2016 through 2020, behind only Oklahoma, according to National Cancer Institute data. And, for non-Hispanic Black women such as Jones, the rates in the state are even higher — 3.7 deaths per 100,000 people. This all translates to about 50 avoidable deaths of Mississippi women from cervical cancer each year in this largely rural state.

Health care experts said such a high death rate from a cancer that is preventable, detectable, and successfully treatable when found early is a warning sign about the general state of health care in Mississippi.

“They desperately need help there,” said Otis Brawley, a professor of oncology at Johns Hopkins School of Medicine and an expert on health disparities. “Political leadership is incredibly important in turning this around, and in Mississippi, the political leadership don’t give a damn.”

Despite the beauty of Mississippi, from the rolling hills of the Natchez Trace to white-sand beaches on the Gulf of Mexico, and the cultural renown of its famous musicians and storytellers, the state’s reputation is marred by its high rates of poverty. People who live there are accustomed to being the butt of jokes, but it hurts.

“Often Mississippi gets represented poorly,” said Mildred Ridgway, an OB-GYN at the University of Mississippi Medical Center in Jackson.

Recently the state has reeled from crisis after crisis. As recently as March, tornadoes and other severe weather killed more than two dozen people and caused extensive damage. Last year, the water in Jackson, the state capital, was undrinkable for months because of treatment plant failures.

On just about any measure of health, Mississippi ranks near or at the bottom. Nationally, an estimated 10% of people under 65 lack health insurance, but in Mississippi it is about 14%. Deaths from cardiovascular disease, diabetes, cancer, and many other illnesses are among the highest per capita in the country.

The high rates of poverty contribute to the high cervical cancer mortality, health experts said. About 19% of Mississippians — nearly 1 in 5 — live in poverty, while nationally it is about 13%.

“If I had to pinpoint what that’s from, it’s from lack of education,” said Ridgway, referring to a lack of knowledge about regular cervical cancer screening, which the U.S. Preventive Services Task Force recommends every three years for women 21 to 65.

But it likely goes far beyond that, many health experts said. Doctors may be less likely to stress preventive care to less educated women and women of color, studies suggest.

“There’s a big difference in the quality of care,” said Rajesh Balkrishnan, a professor of public health at the University of Virginia who has extensively studied oncology care in Appalachia and other underserved areas.

In her case, Jones said, she could not get her doctor’s office to return her calls in a timely manner. She was concerned about her symptoms.

“I felt I wasn’t listened to. I called her more than she called me,” Jones said of her doctor. “I was going to my appointments, and I was ignored.”

And getting access to any care — let alone quality, culturally competent care from providers who acknowledge a patient’s heritage, beliefs, and values during treatment — may be difficult.

Most of the state’s 82 counties are rural. The average travel distance to a grocery store is 30 miles, and half the population lives in a county that is considered medically underserved, said Letitia Thompson, a vice president in Mississippi for the American Cancer Society.

Low-income rural residents often lack reliable transportation, she said, and even if they own a vehicle, they lack gas money. They often can’t find — or pay for — someone to take care of their children so they can go to the doctor. Women with low-paying jobs often lack the time to drive to a clinic in a distant town, or the ability to take off from work without losing pay.

“Women who work and take care of children often have a huge burden of responsibility,” Ridgway said. “They don’t have time or the money.”

Many also don’t have insurance. While the Affordable Care Act has lowered the uninsured rate in Mississippi, an estimated additional 88,000 Mississippians could have coverage through Medicaid if the state expanded eligibility for the federal-state insurance program for low-income Americans. But the state is one of 10 that have not agreed to expand coverage to more adults.

Mississippi Gov. Tate Reeves, a Republican up for reelection this year, is opposed to expansion. His Democratic challenger, Brandon Presley, a second cousin of the music legend Elvis, favors it. Polls show Presley lagging Reeves.

Without expansion of Medicaid, people who have low incomes are often left to decide between forgoing insurance and purchasing a policy through the Affordable Care Act marketplace if they cannot get insurance through employment. Even if they qualify for subsidized marketplace plans, they may face high deductibles or copayments for visits, health experts said. That often means going to the doctor only when sick. Preventive care becomes a luxury.

“You save your health care dollars for when you are sick or your kids are sick,” said Thompson, of the American Cancer Society.

But regular medical care can make all the difference with cervical cancer. Pap tests have long helped detect abnormal cervical cells that could turn malignant. Brawley said the test is “one of the best” cancer screening tests because of its accuracy.

In 2006, vaccines to prevent cervical cancer were first approved by the FDA. The vaccines guard against the common sexually transmitted infection called the human papillomavirus, which causes nearly all cervical cancers. The HPV vaccine is most effective when administered before a person has become sexually active; the federal recommendation is to get the shots by age 12.

Only a handful of places in the U.S. — including Hawaii, Rhode Island, Virginia, Puerto Rico, and the District of Columbia — require the vaccines to attend school. California has pending legislation that initially would have required that middle schoolers get the shots, but the bill has since been watered down to recommend them instead.

Mississippi does not require the vaccine, and the state has had the lowest share of fully vaccinated teens by a large margin for years. Fewer than 39% of teens there were up to date on HPV vaccination as of 2022, according to the CDC, compared with an estimated 63% nationally.

Thompson said she thinks many parents are hesitant to have their children vaccinated because they believe it would encourage sexual activity.

“This is an anti-cancer vaccine,” Thompson said.

Krista Guynes, director of the women’s health program at the Mississippi State Department of Health, said the state has several efforts underway to better inform women about the need for screening. It also has clinics for uninsured women. In partnership with the National Cancer Institute and University of Mississippi Medical Center, she said, the health department is conducting a study to evaluate risk and look for new biomarkers in women undergoing screening for cervical cancer.

As for Jones, she considers herself lucky to have survived stage 3 cancer.

“I would just like to say to every woman, ‘Get the vaccine.’ The vaccine will make the difference, so they won’t have to be told, ‘I’m sorry, you have cancer.’”

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

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When it comes to cancer treatments, most people are familiar with chemotherapy, radiation and surgery. 

Yet there is another emerging, lesser-known therapy that is showing promising results in treating blood cancers.

With CAR T-cell therapy, the patient’s T-cells are taken from the blood, engineered to attack cancer cells and then infused back into the patient’s body through an IV, Dr. Noopur Raje told Fox News Digital.

Raje is the director of Multiple Myeloma at Mass General Cancer Center, which is a member of the Mass General Brigham system. Mass General Brigham has a Gene and Cell Therapy Institute that helps advance gene and cell therapies like CAR-T.

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"I think it's made a big change in people's lives and how we take care of people," she told Fox News Digital in an interview. 

"It's one of the most personalized ways of taking care of some of the blood-related cancers."

At Mass General, Raje and her team treat patients with multiple myeloma, a rare form of blood cancer that attacks the plasma cells. 

Most of their patients are between 60 and 70 years old, she said.

CAR stands for chimeric antigen receptors, which are proteins that enable T-cells to target the tumor antigens produced by cancer cells.

T-cells are a type of white blood cell that helps to fight germs and prevent disease, per the Cleveland Clinic.

There are currently six CAR T-cell therapies that are FDA-approved to treat leukemia, lymphomas, multiple myeloma and other blood cancers.

"We are taking our patients’ T-cells, which are the immune cells, and then activating them and putting a chimeric antigen receptor (CAR), which can recognize a protein on a cancer tumor," Raje said.

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Because Raje treats multiple myeloma, her team started off by doing studies against a protein called BCMA, which is found in cancerous plasma cells.

The re-engineered T-cells continue multiplying in the body, so they can seek out and kill more tumor cells, the doctor said.

"We are seeing extremely high response rates, between 82% and 100%," she told Fox News Digital. "Now we need to do a better job of maintaining that response."

Before CAR T-cell therapy, Raje said, patients were started on a treatment and then stayed on it for an indefinite length of time.

"This is the first time that patients are getting a ‘one-off’ treatment, and then we're just watching them with no more treatment at all," she said.

While the treatment can be a little "involved" at the beginning, Raje said, once it’s complete the patient receives no new therapies for up to three years.

"And I have some patients who are on no treatment for way longer than that, which is a big advancement," she added.

"Obviously, we need to do better — we need to cure people," Raje said. 

"We're not quite there, but the next step is to start the treatment earlier, so we can start seeing more control of the disease over a longer period of time."

As of now, the FDA has approved CAR T-cell therapy as a "last resort" when the disease has persisted through all other available treatments; but Raje hopes that soon, it will be available to patients earlier in the course of their cancers.

CAR T-cell therapy is expensive — costing anywhere from $500,000 to $1,000,000, per WebMD. Raje pointed out, however, that many insurance plans cover at least some of the cost. It is also covered by Medicare.

"I think one has to start looking at the time saved in terms of quality of life in not coming back to the hospital and not being on any other meds," she said.

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There is some risk of side effects for those receiving CAR T-cell therapy, primarily a condition called cytokine release syndrome (CRS). It can occur when the immune system responds too aggressively to infection.

"When the CAR T-cell kills the tumor, it produces a bunch of proteins, and when it does that, it can make you quite sick," Raje said.

"But as we've used more and more of these therapies, we've gotten pretty good at managing this, and we have the antidotes for these kinds of toxicities," she added.

Another potential side effect is a condition called ICANS, or immune effector-mediated neurotoxicity. 

"With this, people can get confused, sometimes to the extent that they can actually go into a deep coma," Raje said. "It's important to recognize and treat these conditions earlier."

Sandy Caterine, a retired accountant who lives in Rye, New Hampshire, was part of a clinical trial for CAR T-cell therapy. 

She was diagnosed with multiple myeloma in August 2019. 

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"It kind of came out of nowhere," Caterine told Fox News Digital. "In retrospect, maybe I had a couple of little symptoms."

Caterine had experienced some back pain, fatigue and nausea, but initially chalked it up to dehydration. 

When the symptoms didn’t go away on their own, she saw her primary care physician and got some blood tests, which led to her diagnosis.

"I had never even heard of multiple myeloma," Caterine said. "All I heard was that it was incurable and no one could predict what the life expectancy might be."

For several months, Caterine was on a regimen of numerous drugs, infusions and radiation, none of which fully resolved her cancer. Then she learned about the clinical trial for CAR T-cell therapy.

"Sandy has what is known as high-risk disease, based on the genetics of the cancer," said Raje. "This usually doesn’t have good outcomes, but Sandy had a great response to the trial."

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Caterine, who is 62, did experience the CRS illness as a side effect, which caused her to endure nausea, fatigue, fever and disorientation. 

She remained in the hospital for 15 days.

"It took me a while to get my strength back," she said. "I do remember them taking very good care of me."

Caterine has gotten periodic bone marrow scans every three months since her infusion.

"So far, there has been no sign of the disease," she said. 

"Dr. Raje told me the hope was that it would work for two to three years, and I am already over two years."

Caterine’s experience has helped her appreciate each day more than she did before, she told Fox News Digital.

"These are two years that I never thought I would get when I was first diagnosed," she said. 

"It's just great that I can continue to live my life and be with my family."

CAR T-cell therapy started out for use in leukemia, later branching out to other blood cancers like lymphoma and multiple myeloma. 

Raje is hopeful that the treatment eventually will become available for other types of cancers, including cancers of the breast, colon and brain.

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"We have an ongoing study where we are looking at CAR T-cell therapy in glioblastoma, a type of brain cancer, which we would have never thought of doing early on," she said. 

"And we have a whole host of new CARs coming down the pike against different antigens."

The doctor emphasized the significance of teaching the body’s own immune cells to fight against cancer cells.

"In my mind, it's probably the most personalized way of being able to take care of your own disease, which is amazing," she said.

Tras una cirugía de emergencia para extirpar el tumor, junto con sus ovarios, útero, trompas de Falopio y apéndice, Hughes contó que vio una publicación en Instagram en la que una mujer con cáncer uterino relacionaba su condición con alisadores químicos para el cabello.

“Casi me desmayo”, dijo desde su casa en Smyrna, Georgia.

Cuando tenía unos 4 años, su madre comenzó a aplicarle un alisador químico, o “relajante”, en el cabello cada seis u ocho semanas. “Quemaba y olía terrible”, recordó Hughes. “Pero era parte de nuestra rutina para ‘lidiar con mi cabello'”.

La rutina continuó hasta que fue a la universidad y conoció a otras mujeres negras que llevaban el cabello de forma natural. Pronto, Hughes dejó de usar alisadores.

Las presiones sociales y económicas han llevado durante mucho tiempo a las niñas y mujeres negras a alisar su cabello para cumplir con los estándares de belleza eurocéntricos. Pero los alisadores químicos tienen un olor desagradable, son costosos y a veces causan quemaduras dolorosas en el cuero cabelludo. Y ahora hay cada vez más evidencia de que podrían ser un riesgo para la salud.

Los alisadores pueden contener carcinógenos, como agentes liberadores de formaldehído, ftalatos y otros compuestos que alteran el sistema endócrino, según estudios de los Institutos Nacionales de Salud. Estas sustancias químicas pueden imitar las hormonas del cuerpo y se han vinculado con cánceres de seno, útero y ovario, muestran investigaciones.

Investigadores y médicos especializados en cáncer dicen que la aplicación frecuente y de por vida de alisadores químicos en el cabello y el cuero cabelludo de mujeres afroamericanas podría explicar por qué los cánceres relacionados con hormonas afectan de manera desproporcionada a mujeres negras en comparación con mujeres blancas.

“Lo que hay en estos productos es perjudicial”, dijo Tamarra James-Todd, profesora de epidemiología en la Escuela de Salud Pública T.H. Chan de Harvard, quien ha estudiado productos alisadores por los últimos 20 años.

James-Todd cree que los fabricantes, legisladores y médicos deberían advertir a los consumidores que los alisadores podrían causar cáncer y otros problemas de salud. Pero los reguladores han sido lentos en actuar, los médicos se han mostrado reacios a tomar la causa, y el racismo continúa dictando los estándares de moda que dificultan que las mujeres dejen los alisadores, productos tan adictivos que son conocidos como “crema adictiva” (“creamy crack”).

Michelle Obama alisó su cabello cuando Barack era presidente porque creía que los estadounidenses “no estaban preparados” para verla con trenzas, dijo la ex primera dama después de dejar la Casa Blanca. El ejército de los Estados Unidos todavía prohibía estilos populares de cabello negro, como rastas y trenzas, mientras el primer presidente negro del país estaba en el cargo.

En 2019, California se convirtió en el primer estado de casi 20 en prohibir la discriminación basada en el cabello. El año pasado, la Cámara de Representantes de los Estados Unidos aprobó una legislación similar, conocida como la Ley CROWN (Creating a Respectful and Open World of Natural Hair). Sin embargo, el proyecto de ley fracasó en el Senado.

La necesidad de legislación destaca los desafíos que enfrentan las niñas y mujeres negras en la escuela y en el lugar de trabajo.

“Tienes que elegir tus batallas”, dijo Ryland Gore, cirujana oncológica con sede en Atlanta. Gore informa a sus pacientes con cáncer de mama sobre el mayor riesgo de cáncer debido a los alisadores. A pesar de su conocimiento, Gore continúa usando alisadores químicos en su propio cabello, como lo ha hecho desde que tenía unos 7 años.

“Tu cabello cuenta una historia”, dijo.

En las conversaciones con sus pacientes, Gore a veces también habla sobre cómo las mujeres afroamericanas solían tejer mensajes en sus trenzas sobre la ruta a seguir en el Underground Railroad mientras buscaban la libertad de la esclavitud.

“Es simplemente una discusión profunda”, que abarca cultura, historia e investigación sobre las prácticas de estilo de peinados actuales, dijo. “Los datos están ahí fuera. Por lo tanto, se les debe advertir a los pacientes, y luego pueden tomar una decisión”.

La primera pista de una conexión entre los productos para el cabello y problemas de salud surgió en la década de 1990. Los médicos comenzaron a ver signos de madurez sexual en bebés y niñas negras que desarrollaban senos y vello púbico después de usar champús que contenían estrógeno o extracto placentario. Cuando las niñas dejaban de usar el champú, el desarrollo del cabello y los senos retrocedían.

Desde entonces, James-Todd y otros investigadores han vinculado compuestos químicos en productos para el cabello con una variedad de problemas de salud más prevalentes entre las mujeres negras, desde la pubertad temprana hasta el parto prematuro, la obesidad y la diabetes.

En los últimos años, los investigadores se han enfocado en una posible conexión entre los alisadores químicos y los cánceres relacionados con hormonas, como el que desarrolló Hughes, que tienden a ser más agresivos y mortales en las mujeres negras.

Un estudio de 2017 encontró que las mujeres blancas que usaban alisadores químicos tenían casi el doble de probabilidades de desarrollar cáncer de seno que aquellas que no los usaban. Debido a que la gran mayoría de las participantes negras del estudio usaban alisadores, los investigadores no pudieron probar efectivamente la asociación en mujeres negras, según afirmó la autora principal, Adana Llanos, profesora asociada de epidemiología en la Escuela de Salud Pública Mailman de la Universidad de Columbia.

Los investigadores lo probaron en 2020.

El llamado Sister Study (Estudio de las Hermanas), una importante investigación del Instituto Nacional de Ciencias de la Salud Ambiental sobre las causas del cáncer de mama y enfermedades relacionadas, hizo el seguimiento de 50,000 mujeres estadounidenses cuyas hermanas habían sido diagnosticadas con cáncer de mama y que estaban libres de cáncer cuando se inscribieron. Independientemente de la raza, las mujeres que informaron haber usado alisadores en el año anterior tenían un 18% más de probabilidades de ser diagnosticadas con cáncer de mama. Aquellas que usaron alisadores al menos cada cinco a ocho semanas tenían un 31% más de riesgo de ese cáncer.

Casi el 75% de las hermanas negras usaron alisadores en el año anterior, en comparación con solo el 3% de las hermanas blancas no hispanas. Tres cuartas partes de las mujeres negras también informaron haber usado alisadores cuando eran adolescentes, y el uso frecuente de alisadores químicos durante la adolescencia aumentó el riesgo de cáncer de mama premenopáusico.

En 2021, un análisis de los datos del Sister Study mostró que las hermanas que usaban frecuentemente alisadores o productos para el alisado tenían el doble de riesgo de cáncer de ovario. Otro análisis, en 2022, encontró que el uso frecuente aumentaba en más del doble el riesgo de cáncer de útero.

Después de que los investigadores descubrieron la relación con el cáncer de útero, algunos pidieron cambios en las políticas y otras medidas para reducir la exposición a los alisadores.

“Es hora de intervenir”, escribió Llanos y sus colegas en un editorial que acompañó el análisis del cáncer de útero. Aunque reconocen la necesidad de más investigaciones, lanzaron un “llamado a la acción”.

Nadie puede afirmar que el uso de alisadores permanentes causará cáncer, dijo Llanos en una entrevista. “Así no funciona el cáncer”, dijo, señalando que algunos fumadores nunca desarrollan cáncer de pulmón, a pesar de que el tabaquismo es un factor de riesgo conocido.

El corpus de investigación sobre los alisadores para el cabello y el cáncer es más limitado, dijo Llanos, quien dejó de usar alisadores químicos hace 15 años. Pero preguntó retóricamente: “¿Necesitamos investigar durante otros 50 años para saber que los alisadores químicos son perjudiciales?”.

Charlotte Gamble, ginecóloga oncológica cuya práctica en Washington, D.C., incluye a mujeres negras con cáncer de útero y ovario, dijo que ella y sus colegas ven los hallazgos del estudio sobre el cáncer de útero como dignos de una exploración más profunda, pero aún no deberían discutirse con los pacientes.

“Aún tengo mis dudas”, dijo. “Se necesita mucha más información”.

Mientras tanto, James-Todd y otros investigadores creen que han construido un sólido corpus de evidencia.

“Hay suficientes cosas que sí sabemos como para comenzar a tomar medidas, desarrollar intervenciones, proporcionar información útil a los médicos, pacientes y al público en general”, dijo Traci Bethea, profesora asistente en la Oficina de Salud de las Minorías e Investigación sobre Disparidades en Salud de la Universidad de Georgetown.

La responsabilidad de regular los productos de cuidado personal, incluidos los alisadores químicos para el cabello y las tinturas, que también se han vinculado con cánceres relacionados con hormonas, recae en la Administración de Alimentos y Medicamentos (FDA).

Sin embargo, la FDA no somete los productos de cuidado personal al mismo proceso de aprobación que utiliza para alimentos y medicamentos. La FDA solo restringe 11 categorías de productos químicos utilizados en cosméticos, mientras que las preocupaciones sobre los efectos en la salud han llevado a la Unión Europea a restringir al menos 2,400 sustancias.

En marzo, las representantes Ayanna Pressley (demócrata de Massachusetts) y Shontel Brown (demócrata de Ohio) pidieron a la FDA que investigara la posible amenaza para la salud que representan los alisadores químicos. Un representante de la FDA dijo que la agencia lo investigaría.

Los peinados naturales están resurgiendo entre las niñas y mujeres negras, pero muchas siguen dependiendo de la “crema adictiva”, según Dede Teteh, profesora asistente de salud pública en la Universidad Chapman.

Teteh tuvo su primer alisado permanente a los 8 años y ha luchado por dejar los alisadores de adulta. Ahora usa trenzas estilo “locs”. Hace poco, consideró alisarse químicamente el cabello para una entrevista de trabajo académica porque no quería que su cabello “fuera un obstáculo” cuando se presentara ante profesores blancos.

Teteh lideró un proyecto de investigación sobre la salud del cabello llamado “The Cost of Beauty” (El Costo de la Belleza) publicado en 2017. Ella y su equipo entrevistaron a 91 mujeres negras en el sur de California. Algunas reaccionaron de manera “combativa” ante la idea de dejar los alisadores y afirmaron que “todo puede causar cáncer”.

Sus reacciones reflejan los desafíos que enfrentan las mujeres negras en Estados Unidos, dijo Teteh.

“No es que la gente no quiera escuchar información relacionada con su salud”, dijo. “Pero quieren que la información se comparta de manera empática con la difícil situación de ser negra aquí en los Estados Unidos”.

Kara Nelson de KFF Health News colaboró con este informe.

Este artículo fue producido por KFF Health News, que publica California Healthline, un servicio editorialmente independiente de la  California Health Care Foundation. 

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

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The World Health Organization (WHO) released its official statement this week on the potential health risks of aspartame, with a committee classifying the non-sugar, low-calorie sweetener as "possibly carcinogenic to humans."

Many industry experts, however, are speaking out in defense of aspartame, which is commonly used in diet sodas, chewing gum, some dairy products and many other low-calorie foods and beverages.

The International Agency for Research on Cancer (IARC), a cancer-focused organization within WHO, was the agency that called out the sweetener’s potential cancer risk.

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The IARC uses five different levels of cancer risk: Group 1, "carcinogenic to humans"; Group 2A, "Probably carcinogenic to humans"; Group 2B: "Possibly carcinogenic to humans"; Group 3, "Unclassifiable as to carcinogenicity in humans"; and Group 4, "Probably not carcinogenic to humans."

Aspartame was placed in Group 2B based on "limited evidence" of causing cancer in humans and animals — particularly a type of liver cancer, the press release stated.

In the same announcement, the Joint Expert Committee on Food Additives (JECFA), another group within WHO, seemed to contradict the IARC’s classification.

"JECFA also considered the evidence on cancer risk, in animal and human studies, and concluded that the evidence of an association between aspartame consumption and cancer in humans is not convincing," the press release stated.

The acceptable daily intake (ADI) of aspartame remains 40 milligrams per kilogram of body weight, JECFA also said. That amount is the equivalent of nine cans of 12-ounce diet soda per day for a 150-pound person.

(The FDA recommends an even higher ADI, at 50 milligrams per kilogram of body weight.)

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"Our results do not indicate that occasional consumption should pose a risk to most consumers," Dr. Francesco Branca, director of the Department of Nutrition and Food Safety at the WHO, stated during a press conference in Geneva.

Dr. Mona S. Jhaveri, a biotech scientist and cancer researcher in Ridgefield, Connecticut, told Fox News Digital that the likelihood of getting cancer depends on the types and the number of carcinogens that one is exposed to, as well as genetic factors. 

"Carcinogens can work either alone or in combination with other substances," she said. 

Often, she added, "people who are subject to multiple carcinogens can increase their risk of getting cancer exponentially."

Many industry experts maintain that aspartame is still safe for consumption — including the FDA, which released a statement refuting the cancer risk.

"The FDA disagrees with IARC’s conclusion that these studies support classifying aspartame as a possible carcinogen to humans," the statement read. 

"FDA scientists reviewed the scientific information included in IARC’s review in 2021 when it was first made available and identified significant shortcomings in the studies on which IARC relied."

"We note that JECFA did not raise safety concerns for aspartame under the current levels of use and did not change the acceptable daily intake (ADI)."

Additional agencies, including the European Food Safety Authority and Health Canada, have also deemed aspartame to be safe at the current recommended levels, the FDA added.

"Aspartame is one of the most studied food additives in the human food supply," the FDA stated. 

"FDA scientists do not have safety concerns when aspartame is used under the approved conditions."

Dr. Arnold Baskies, a New Jersey-based surgical oncologist and past chairman of the National Board of Directors of the American Cancer Society — he's also a member of the Coalition for Safe Food and Beverage Choices Expert Advisory Committee — pointed out that the WHO agencies, IARC and JECFA, reviewed previous research. They did not review new evidence.

"The WHO Joint Expert Committee on Food Additives’ (JECFA) review says that aspartame is safe for human consumption," Baskies said in a statement provided to Fox News Digital. "JECFA is the authoritative international agency when it comes to food safety."

The FDA relies on JECFA’s assessments as part of its process of determining the safety and risks of foods and beverages, Baskies noted.

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"It is irresponsible to needlessly scare or confuse people," he said. "If there was any cause for concern, they would have adjusted the current acceptable daily intake (ADI)."

The Calorie Control Council (CCC) in Atlanta, Georgia, also spoke out in defense of aspartame as a safe food additive.

"The JECFA ruling not only confirms the four decades of science concluding aspartame is safe, but also provides real-life ‎context around the safe consumption of this ingredient," said Robert Rankin, president of the CCC, in a statement sent to Fox News Digital.

Any risk is highly unlikely given the JECFA’s guidelines for recommended daily intake, Rankin also said.

"The average 150-pound person would need to consume about 14 12-oz. cans of diet beverages or about 74 packets of aspartame-containing tabletop sweetener every day over the course of their life to raise any safety concern," Rankin said.

"Obviously, that level of consumption is not realistic or recommended, nor is it ‎aligned with the intended use of these ingredients."

Regarding IARC describing aspartame as "possibly cancer-causing," Rankin stated that IARC is not a regulatory agency or food safety authority, and said that its classification is "misleading, inaccurate and [constitutes] fearmongering."

He said, "IARC looks for substances that could potentially cause cancer without considering actual dietary intake, and has found many things, such as drinking hot water and working at night, to be probably carcinogenic."

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"It is not only wrong, but potentially damaging to certain populations to position IARC’s report alongside true scientific and regulatory agencies like JECFA, the Food and Drug Administration, and the European Food Safety Authority," Rankin added.

Dr. Ernest Hawk, head of the Division of Cancer Prevention and Population Sciences at The University of Texas MD Anderson Cancer Center, also spoke to Fox News Digital about aspartame’s safety.

"IARC classified aspartame as ‘possibly carcinogenic to humans’ based on limited evidence for cancer in humans and experimental animals, and limited evidence that it might behave as a carcinogen," he said. 

"Because all of the evidence was limited, aspartame was added to WHO’s list of possible carcinogens."

The list begins with 126 agents known to be carcinogenic in humans (including tobacco and alcohol) and 94 agents that are "probably carcinogenic" — followed by 322 agents that are "possibly carcinogenic," Hawk explained.

"Aspartame will now be included in that final group, but keep in mind that none of those have been convincingly proven to cause cancer," he added.

The FDA, the National Cancer Institute, the American Institute for Cancer Research and the American Cancer Society all have evaluated the same evidence in the past, and all of them concluded that there was no clear evidence that artificial (non-nutritive) sweeteners cause cancer when consumed at typical levels, Hawk said.

While he believes that the WHO agencies did a careful review and have the public’s best interest in mind, Hawk called for additional research on the long-term health risks of consuming non-sugar sweeteners.

The FDA and other health agencies do not agree that aspartame is a cancer risk, so some medical professionals recommend using sugar instead of artificial sweeteners.

"Although it’s approved by regulatory bodies, potential risk factors are associated with preferring aspartame over sugar," noted Jhaveri.

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"Sensitivities or allergies to aspartame can result in adverse reactions, and excessive consumption may contribute to weight gain due to heightened cravings for sweet edibles," she said.

For some people, aspartame may cause physical symptoms that include headaches, dizziness, digestive ailments and allergic responses, Jhaveri noted.

"Avoiding aspartame when possible and opting for natural sugars in fruits and vegetables is prudent," she said. 

In May, the WHO advised against the use of non-sugar sweeteners like aspartame for the purposes of controlling body weight or lowering the risk of non-communicable diseases.

"Replacing free sugars with NSS does not help with weight control in the long term," said Branca, the WHO’s director for nutrition and food safety, in a press release at the time. 

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For the general public, Hawk recommended "paying attention to the science" as it continues to develop regarding the possible health consequences of artificial sweeteners.

"In the meantime, continue to work on consistently eating a balanced, healthy diet that contains whole foods that are high in nutrient density," he suggested.

People with a rare inherited disorder called phenylketonuria (PKU) should avoid aspartame, medical experts say.

Those with PKU don’t have the enzyme to break down an amino acid called phenylalanine, so it builds up in the body. 

Consuming foods and drinks with aspartame can cause dangerous levels of phenylalanine that can lead to serious health issues, according to the Mayo Clinic’s website.

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Aspartame-containing products will include a warning on the label stating "PHENYLKETONURICS: CONTAINS PHENYLALANINE." 

Anyone with PKU should avoid any food or drink with this warning.

The reasons can vary, from quality control failures at manufacturing plants to surging demand, including significant interest that has at times squelched availability of drugs taken for weight loss.

But the problem is not easily fixed. Most active pharmaceutical ingredients are made in China, and boosting production in the U.S. is not like flipping a switch. Many of the drugs in short supply are generics made in India, where regulators often find serious production lapses. So what to do? Along with a colleague, Marta Wosińska, a senior fellow in economic studies at The Brookings Institution, has three ideas to alleviate shortages of generic sterile injectable medicines, in particular. They suggest the U.S. government should provide incentives to upgrade facilities and create a buffer inventory. But they also argue hospital purchasing is in need of an overhaul. We discussed the possibilities; our conversation has been lightly edited. 

I’ve been writing about drug shortages on and off for many years, but the problem never goes away. And now, it seems even worse. Obviously, something has to change. But what exactly has been lacking with our policies to date?

Continue to STAT+ to read the full story…